Left ventricular aneurysm (LVA) is one of the most important complications of myocardial infarction LVA is strictly defined as a distinct area of abnormal left ventricular diastolic contour with systolic dyskinesia or paradoxical bulging. LVA usually results from myocardial infarction. Other rare aetiologies of LVA include hypertrophic cardiomyopathy, Chagas' disease, sarcoidosis, congenital LV...

Cardiomyopathy is a major cause of death worldwide. Based on pathohistological abnormalities and clinical manifestation, cardiomyopathies are categorized into several groups: hypertrophic, dilated, restricted, arrhythmogenic right ventricular, and unclassified. Dilated cardiomyopathy, which is characterized by dilation of the left ventricle and systolic dysfunction, is the most severe and preva...

Dilated cardiomyopathy can be the end-stage form and common denominator of several cardiac disorders of known cause, such as hypertensive, ischemic, diabetic and Chagasic diseases. However, some individuals have clinical findings, such as an increase in ventricular chamber size and impaired contractility (classical manifestations of dilated cardiomyopathy) even in the absence of a diagnosed pri...

Potassium ions are vital for maintaining functionality of K channels. In their absence, many K channel types enter a long-lasting defunct condition characterized by absence of conductance and drastic changes in gating current. We show that channels pass through a dilated condition with altered selectivity as they are becoming defunct. To characterize these abnormalities we examined gating and i...

BACKGROUND TNF-like weak inducer of apoptosis (TWEAK) has been reported to predict mortality in patients with dilated cardiomyopathy. However, whether it can be used as a biomarker for disease monitoring or rather represents a risk factor for disease progression remains unclear. AIM OF THE STUDY To evaluate the potential of sTWEAK as a biomarker in patients with dilated cardiomyopathy. RESU...

Notoriously, learning with recurrent neural networks (RNNs) on long sequences is a difficult task. There are three major challenges: 1) extracting complex dependencies, 2) vanishing and exploding gradients, and 3) efficient parallelization. In this paper, we introduce a simple yet effective RNN connection structure, the DILATEDRNN, which simultaneously tackles all these challenges. The proposed...

A 59-year-old man with alcoholic liver disease became comatose from a left acute subdural hematoma. He developed a fixed dilated right pupil but the left pupil was responsive to light. Oculovestibular responses were normal. He had right extensor posturing. At autopsy uncal herniation was not found, but there was a diagonally shifted and rotated brainstem likely tethering or compressing the cont...

Compared with other cardiovascular diseases, heart muscle disease (cardiomyopathy) is relatively rare. In its most common form, the disease accounts for only 50,000 new cases in the United States each year, while the annual number of stroke cases, for example, reaches 500,000. Unlike many other cardiovascular disorders that tend to affect the elderly, cardiomyopathy commonly occurs in the young...

A 31-year-old white man was referred for investigation of a persistent sinus tachycardia. His only significant past medical history was of chronic schizophrenia for which he had been taking clozapine for six years. An electrocardiogram demonstrated sinus tachycardia, voltage criteria for left ventricular hypertrophy, and a prolonged QTc. Echocardiographic findings were consistent with a dilated...

OBJECTIVE Cardiomyopathy, a popular diagnosis that always obscures more than it reveals, nevertheless has several characteristic histological features. These prominently include widespread focal myocardial fibrosis and associated hypertrophy of surviving cardiac myocyte. In fact, focal noninflammatory degeneration (not necrosis) has been demonstrated as a feature of many forms of cardiac hypert...