Abstract A new multistage synthesis of the N-borylated dipeptide B 12 -PheGlyOH has been proposed. The approach is based on reaction nucleophilic addition amino acid derivatives to [B H 11 NCCH 3 ] – anion. products each stage have characterized by multinuclear NMR spectroscopy, IR absorption and ESI mass spectrometry.

The alpha-aminoisobutyric acid-D-proline (Aib-(D)Pro) dipeptide is an obligatory Type I' beta-turn forming segment that nucleates hairpin formation.

Incorporation of dextran into a hydrogel formed using a low molecular weight dipeptide-conjugate gelator results in controlled modification of the material properties.

Histidyl-proline diketopiperazine is produced in brain as a product of the metabolism of thyrotropin-releasing hormone. A number of the previously observed central nervous system and pituitary activities resulting from an exposure to thyrotropin-releasing hormone appear to involve the conversion of the releasing factor to the cyclic dipeptide. In the present study, the development of a rabbit a...

PURPOSE Premature infants undergoing intensive care are highly vulnerable to amino acid deprivation. Supplementation of glutamine or arginine has resulted in beneficial effects in human neonates. This study was conducted to examine the effect of the dipeptide arginyl-glutamine (Arg-Gln) on vascular endothelial cell growth factor (VEGF) levels in primary human retinal pigment epithelial (hRPE) c...

Among three biologically active substrates of angiotensin-converting enzyme, enzyme-binding affinities increase and chloride ion rate enhancements decrease in the following order: angiotensin I (Asp-Arg-Val-TyrIle-His-Pro-Phe-His-Leu), bradykinin (Arg-Pro-ProGly-Phe-Ser-Pro-Phe-Arg), bradykinin-potentiating peptide 5, (<Glu-Lys-Trp-Ala-Pro). Qualitatively simil a r properties are observed among...