Plague is an endemic disease to the west of Iran and has frequently stricken this area over the last decades. In 1954, Pasteur Institute of Iran established a research station in the west of the country and since then has monitored the plague outbreaks as well as the disease status in rodents and carnivores by dispatching research teams to different villages and localities. We noticed that ther...

The investigation of infectious disease outbreaks relies on the analysis of increasingly complex and diverse data, which offer new prospects for gaining insights into disease transmission processes and informing public health policies. However, the potential of such data can only be harnessed using a number of different, complementary approaches and tools, and a unified platform for the analysi...

We use mathematically rigorous definitions of epidemiological concepts in order to derive a sequential combinatorial model of disease outbreak decomposition. We define the idea of a population specific 'disease signature' and use this in order to decompose and further understand outbreaks as incidents of spatial and temporal spread of disease exposure both in, and across, populations. This allo...

Investigating a disease outbreak requires examination of both affected and unaffected animals with the goal of identifying factors associated with the occurrence of disease. By following a series of systematic steps, an unbiased, organized assessment of the problem can be made, and the likelihood of understanding a disease outbreak is increased. Authors’ address: Dept. of Clinical Sciences, Col...

Pandemics associated with emerging infectious diseases, particularly zoonotic infections, are increasing in both frequency and impact. Over the past decade, attempts to control deadly zoonotic viruses like severe acute respiratory syndrome (SARS) and Middle Eastern respiratory syndrome (MERS) coronaviruses, and highly pathogenic avian influenza viruses, have been, out of necessity, almost entir...

BACKGROUND Diarrheal illness remains a leading cause of global morbidity and mortality, with the majority of deaths occurring in children <5 years of age. Lack of resources often prohibits the evaluation of outbreak characteristics and limits progress in managing this important disease syndrome, particularly in Africa. Relying only on existing medical staff and hospital resources, we assess the...