RATIONALE Obesity increases the risk and severity of sleep-disordered breathing. The degree to which excess body weight contributes to blood oxygen desaturation during hypopneic and apneic events has not been comprehensively characterized. OBJECTIVES To quantify the association between excess body weight and oxygen desaturation during sleep-disordered breathing. METHODS A total of 750 adult...

Development of drug treatments for obstructive sleep-disordered breathing has been impeded by the lack of animal models. The obese pig may be a suitable animal model, as it has been reported to experience sleep-disordered breathing resembling human obstructive sleep apnea. The purpose of this paper is to describe in detail techniques for chronic instrumentation of the obese Vietnamese pot-belli...

We studied the effects of medroxyprogesterone acetate, a respiratory stimulant, on the incidence and duration of episodes of apnea and disordered breathing in 13 nonhypercapnic men with obstructive sleep apnea. Nocturnal polysomnography was done before and after four weeks of treatment with medroxyprogesterone acetate (60 mg/day) and one week after cessation of treatment. There were no signific...

Background: Studies have revealed a strong link between sleep-related breathing disorders and essential hypertension. However, the trends of sleep-disordered breathing in hypertensive patients have not been analyzed frequently. Methods: In this prospective, single-center and observational study, random patients with systemic essential hypertension, who were visiting GSVM Medical College, Kanpur...

BACKGROUND Sleep-disordered breathing is associated with major morbidity and mortality. However, its prevalence has mainly been selectively studied in populations at risk for sleep-disordered breathing or cardiovascular diseases. Taking into account improvements in recording techniques and new criteria used to define respiratory events, we aimed to assess the prevalence of sleep-disordered brea...

The first series of children with obstructive sleep apnoea syndrome was reported in 1976. Later it became apparent that children may have breathing disorders during sleep without frank apnoea or 'hypopnoeas'. This pattern could be detected by measuring the oesophageal pressure. This led to the concept of sleep-disordered breathing as a spectrum that combines obstructive sleep apnoea syndrome an...

Acromegaly is the result of oversecretion of growth hormone and IGF-1 and the disease can affect several organ systems. Sleep Disordered Breathing (SDB) is a frequent disease in acromegaly patients. The mechanism of SDB is somewhat different in acromegaly patients than SDB in normal population. Although central apneas can be seen, obstructive apneas according to structural changes complicate th...

Sleep disordered breathing is frequently associated with repeated arousals and hypoxia resulting from intermittent partial or complete collapse of upper airway during sleep. There is an emerging recognition of the association of this disorder with metabolic abnormalities, coronary artery disease, congestive heart failure and hypertension. Of these conditions, the data associating obstructive sl...

Sleep disordered breathing (SDB) in childhood is linked with significant end-organ dysfunction across various systems, particularly with cardiovascular, neurocognitive and metabolic consequences. If we understand the pathophysiology of SDB, diagnose it promptly and treat appropriately, we may be able to prevent morbidity associated with SDB and also save health resources around the world. In th...

Sleep-disordered breathing is common after stroke and most often presents as obstructive sleep apnea (OSA), with an estimated prevalence between 43% and 70% compared with 4% and 24% in the general population. OSA is the result of partial or complete closure of the upper airway while attempting to breathe during sleep. It is characterized by snoring, hypopnea, and apnea with intermittent awakeni...