Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...

The effects of religion, population sub-division and geography on the prevalence of deaf-mutism were investigated using information collected in the 1921 Census of Punjab. The total sample size was 9.36 million, and comprised data on thirteen Hindu castes, seventeen Muslim biraderis and two Sikh castes. A two-way analysis of variance comparing males in Hindu castes in which consanguineous marri...

This paper uses data from the German Socio-economic Panel Study to examine the effect of psychological traits, in particular personality, on the formation and dissolution of marital and cohabiting relationships. Personality traits have substantial effects on propensities to marry and divorce. Changing patterns of selection into and out of domestic partnerships indicate that the determinants of ...

Children are increasingly part of cohabiting unions. The marriage literature indicates that children generally promote stability of marriages but it remains unknown whether children have a similar effect on the stability of their parent’s cohabiting unions. Using the National Survey of Family Growth this paper evaluates the effects of children on the stability of cohabitation. This paper expand...

As part of the largest, longest running prospective American study of same-sex parent families, the present investigation examined relationship dissolution in planned lesbian families. Data were collected from 40 separated couples and their 17-year-old adolescent offspring—19 girls and 21 boys. Nearly all breakups occurred before the former couples could have obtained the legal equivalent of sa...

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...

Understanding how marital patterns affect the Social Security program and its beneficiaries has become an important policy and academic focus. Over the past several decades, a convergence of economic, demographic, and social changes has given rise to dramatic changes in marital trends in the United States. Divorce rates surged in the 1960s and 1970s, the age of first marriage has risen, and the...

Genomic imprinting is predicted to influence behaviors that affect individuals to whom an actor has different degrees of matrilineal and patrilineal kinship (asymmetric kin). Effects of imprinted genes are not predicted in interactions with nonrelatives or with individuals who are equally related to the actor's maternally and paternally derived genes (unless a gene also has pleiotropic effects ...

We investigate the role of parenthood on the outcomes of nonmarital unions for two cohorts of British women between the ages of 16 and 29. We compare the effect of conceptions leading to births and the presence and characteristics of children on the odds that a cohabitation is dissolved, or that it is converted to marriage, for women born in 1958 and 1970. A multilevel multiprocess competing ri...

Demographic trends in the 2000s showed the continuing separation of family and household due to factors such as childbearing among single parents, the dissolution of cohabiting unions, divorce, repartnering, and remarriage. The transnational families of many immigrants also displayed this separation, as families extended across borders. In addition, demographers demonstrated during the decade t...