OBJECTIVES To study the association between impaired fasting glucose (IFG) and arterial stiffness in older adults. DESIGN Cross-sectional population-based study. SETTING The Rotterdam Study, a Dutch population-based cohort study. PARTICIPANTS Two thousand nine hundred eighty-seven subjects aged 60 and older. MEASUREMENTS Arterial stiffness assessed by measuring common carotid arterial d...

INTRODUCTION Increased blood pressure (BP) variability is a cardiovascular risk marker for young individuals and may relate to the ability of their aorta to buffer cardiac output. We used a multimodality approach to determine relations between central and peripheral arterial stiffness and BP variability. METHODS We studied 152 adults (mean age of 31 years) who had BP variability measures base...

Changes in arterial stiffness and structure occur during cardiovascular diseases and can be modified by angiotensin-converting enzyme (ACE) inhibitors. In the present study we investigated the role of membrane-bound ACE (t-ACE) in the regulation of arterial structure and mechanics. Large and small arteries of t-ACE-/- mice were isolated to determine the passive pressure-diameter relationship. W...

I T HAS been known for some time that aging is associated with a reduction in the distensibility of the aorta and large arteries.‘g2 Recent evidence suggests that these age-related changes may be detected in man by means of the externally recorded carotid pulse wave.3-5 Furthermore, pharmacologic agents that alter arterial distensibility change the configuration of the carotid wave in the expec...

The purpose of this investigation was to assess the interactive influence of sympathetic activation and supplemental NO on brachial artery distensibility versus its diameter. It was hypothesized that a) sympathetic activation and nitric oxide competitively impact muscular conduit artery (brachial artery) mechanics, and b) neurogenic constrictor input affects conduit vessel stiffness independent...

Although several studies have shown that exogenous estrogens have beneficial effects on arterial characteristics, the effect of endogenous estrogen on the vascular system is still unknown. In this study, distensibility, an indicator of arterial elasticity, of the common carotid artery was compared in pre- and postmenopausal women. The study comprised 93 premenopausal and 93 postmenopausal women...

Increased aortic stiffness and retinal arteriolar narrowing are subclinical vascular effects of chronic hypertension and predict future cardiovascular events. The relationship between these 2 vascular measures is uncertain and is examined in the Multi-Ethnic Study of Atherosclerosis. This cross-sectional analysis involves 3425 participants (aged 45 to 85 years) free of clinical cardiovascular d...