Cajal compartments aking advantage of the large size of Xenopus oocyte nuclear structures, Handwerger et al. (page 495) analyze in detail the trafficking between the Cajal body and the nucleoplasm. The work provides direct evidence that the Cajal body, discovered a century ago, is a dynamic organelle through which proteins and RNAs move, and not simply a storage site for proteins and RNA involv...

Fix a Pareto optimal, strategy proof and non-bossy deterministic matching mechanism and define a random matching mechanism by assigning agents to the roles in the mechanism via a uniform lottery. Given a profile of preferences, the lottery over outcomes that arises under the random matching mechanism is identical to the lottery that arises under random serial dictatorship, where the order of di...

Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...

The needs of the pore ccording to a model that has prevailed since the early 1990s, nuclear import complexes need to dock to the cytoplasmic filaments of the nuclear pore complex (NPC) before they can be translocated to the nucleus. On page 63, Walther et al. A overturn this idea, demonstrating that cytoplasmic filaments have no essential function in the nuclear import of bulk cargos. The resul...