نتایج جستجو برای: dna vaccine

تعداد نتایج: 607386  

Journal: :Vaccine 2016
Paul Spearman Mark Mulligan Evan J Anderson Andi L Shane Kathy Stephens Theda Gibson Brooke Hartwell Drew Hannaman Nora L Watson Karnail Singh

Plasmodium falciparum malaria is one of the leading infectious causes of childhood mortality in Africa. EP-1300 is a polyepitope plasmid DNA vaccine expressing 38 cytotoxic T cell epitopes and 16 helper T cell epitopes derived from P. falciparum antigens expressed predominantly in the liver phase of the parasite's life cycle. We performed a phase 1 randomized, placebo-controlled, dose escalatio...

2013
Ganzhu Feng Qingtao Jiang Mei Xia Yanlai Lu Wen Qiu Dan Zhao Liwei Lu Guangyong Peng Yingwei Wang

Development of a novel and effective vaccine against Mycobacterium tuberculosis (M.tb) is a challenging for preventing TB infection. In this study, a novel nanoparticle-based recombinant DNA vaccine was developed, which contains Esat-6 three T cell epitopes (Esat-6/3e) and fms-like tyrosine kinase 3 ligand (FL) genes (termed Esat-6/3e-FL), and was enveloped with chitosan (CS) nanoparticles (nan...

2008
Ralf Geiben-Lynn John R. Greenland Kwesi Frimpong-Boateng Nico van Rooijen Norman L. Letvin

There is evidence that the limited immunogenicity of plasmid DNA vaccines is the result, at least in part, of the rapid clearance of vaccine antigen expression by antigen-specific immune responses. However, the cell types responsible for the clearance of plasmid DNA vaccine antigens are not known. Here we demonstrate that macrophages, NK cells, and CD8 T cells did not significantly contribute t...

Journal: :Blood 2008
Ralf Geiben-Lynn John R Greenland Kwesi Frimpong-Boateng Nico van Rooijen Avi-Hai Hovav Norman L Letvin

There is evidence that the limited immunogenicity of plasmid DNA vaccines is the result, at least in part, of the rapid clearance of vaccine antigen expression by antigen-specific immune responses. However, the cell types responsible for the clearance of plasmid DNA vaccine antigens are not known. Here we demonstrate that macrophages, NK cells, and CD8(+) T cells did not significantly contribut...

Journal: :Infection and immunity 2004
Hans Joachim Mollenkopf Leander Grode Jens Mattow Maik Stein Peggy Mann Bernhard Knapp Jeffrey Ulmer Stefan H E Kaufmann

Information from comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guerin (BCG) principally allows prediction of potential vaccine candidates. Thirty-six M. tuberculosis DNA vaccine candidates identified by comparative proteome analysis were evaluated in the mouse model for protection against low-dose aerosol M. tuberculosis infection. We iden...

Journal: :Parasite 2009
W G Chalé-Balboa M Mut-Martin M J Ramirez-Sierra M R Garcia-Miss E Dumonteil

Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infectio...

Journal: :Human Vaccines & Immunotherapeutics 2014

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Wei Kong Matthew Brovold Brian A Koeneman Josephine Clark-Curtiss Roy Curtiss

We previously developed a biological containment system using recombinant Salmonella Typhimurium strains that are attenuated yet capable of synthesizing protective antigens. The regulated delayed attenuation and programmed self-destructing features designed into these S. Typhimurium strains enable them to efficiently colonize host tissues and allow release of the bacterial cell contents after l...

Journal: :Biopolymers and Cell 2005

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