As electrophysiologists we confront the challenge of articulating the risks and benefits of various management options to our patients and their families. Weighing the upfront risk typically associated with an interventional procedure against potential adverse events in the long term is a vexing problem that we frequently face in clinical practice. This discussion involves both the immediate ri...

Forty two years I've been in the ministry. Seen a lot of things. Do you know what I've noticed? Christianity is trendy. Especially in this country where everyone follows the winds of change to exploit change. Here is what I've noted. 1. Crusades and mass meetings: These were in the 50's and 60's. (Before me, mind you.) Billy Graham made them famous but this was the American means of educational...

Reactive systems are. generally, highly successful for dynamic uncertain domains. Analysing why this should be so indicates the main criterion for success is that information apprehended about a given situation can render it certain enough to reliably inform action. A case is made for informing action by dynamic world modelling for domains where this does not hold. When the issue of attending s...

The SLX4 protein functions as a platform for catalytic subunits of structure-specific endonucleases. Findings reported in Cell (Fekairi et al., 2009; Svendsen et al., 2009) and in Molecular Cell (Andersen et al., 2009; Muñoz et al., 2009) now identify the human SLX4 and show that in association with the SLX1 endonuclease it directs the symmetric cleavage and resolution of Holliday junctions.

As electrophysiologists we confront the challenge of articulating the risks and benefits of various management options to our patients and their families. Weighing the upfront risk typically associated with an interventional procedure against potential adverse events in the long term is a vexing problem that we frequently face in clinical practice. This discussion involves both the immediate ri...

Conferences are important. They allow researchers to learn about the latest research, to present and defend their own work, and, most importantly, they provide ample opportunities for networking. However, scientific conferences have come under attack for their climate impact, in particular for the CO2 emissions caused by air travel [1]. The situation is particularly ironic for climate researche...

Nearly everyone agrees that helping patients to plan ahead by defining their goals of care is a worthy endeavor. Those who disagree probably have the good sense to keep it to themselves. Advance care planning (ACP) is one way to aspire to the triple aim of improving care, improving health, and reducing costs, promoted by the Institute for Healthcare Improvement, the Centers for Medicare and Med...