The adhesion of integrins to the extracellular matrix is regulated by binding of the cytoskeletal protein talin to the cytoplasmic tail of the β-integrin subunit. Structural studies of this interaction have hitherto largely focused on the β3-integrin, one member of the large and diverse integrin family. Here, we employ NMR to probe interactions and dynamics, revealing marked structural diversit...

The theory of risk provides a systematic approach to handling uncertainty with well-defined risk and deviation measures. As the model-based economic optimization of the water-flooding process in oil reservoirs suffers from high levels of uncertainty, the concepts from the theory of risk are highly relevant. In this paper, the main focus is to offer an asymmetric risk management, i.e., to maximi...

In modeling the joint upper tail of a multivariate distribution, a fundamental deficiency of classical extreme value theory is the inability to distinguish between asymptotic independence and exact independence. In this work, we examine multivariate threshold modeling based on the framework of regular variation on cones. Tail dependence is described by an angular measure, which in some cases is...

In this work, we examine the role of curvature and surfactant packing in controlling the structure of periodic silica/surfactant composites by driving such materials through a transformation from a hexagonal to a lamellar phase. We focus on how the interplay of desired packing and volume constraints dictates the resulting structures. In general, surfactants expand in a complex way upon heating,...

The genome of Ceriporiopsis subvermispora includes 13 manganese peroxidase (MnP) genes representative of the three subfamilies described in ligninolytic fungi, which share an Mn(2+)-oxidation site and have varying lengths of the C-terminal tail. Short, long and extralong MnPs were heterologously expressed and biochemically characterized, and the first structure of an extralong MnP was solved. I...

In this paper we propagate a large deviations approach for proving limit theory for (generally) multivariate time series with heavy tails. We make this notion precise by introducing regularly varying time series. We provide general large deviation results for functionals acting on a sample path and vanishing in some neighborhood of the origin. We study a variety of such functionals, including l...

We describe the asymptotic behavior of conditional least squares estimator offspring mean for subcritical strongly stationary Galton–Watson processes with regularly varying immigration tail index ? ? ( 1 , 2 ) . The limit law is ratio two dependent stable random variables indices ? and 3 respectively, it has a continuously differentiable density function. use point process technique in proofs.

BACKGROUND Rapunzel syndrome is a rare and unique form of trichobezoar, in which a cast of hairs is formed in the stomach with its 'tail' extending up to varying lengths into the small bowel. Almost all cases described in literature are of 'classic' and more common form of Rapunzel. Sometimes however, the tail of bezoar is broken into smaller fragments. There is not much literature available on...

This paper presents the impact of a class of transformations of copulas in their upper and lower multivariate tail dependence coefficients. In particular we focus on multivariate Archimedean copulas. In the first part of this paper, we calculate multivariate tail dependence coefficients when the generator of the considered copula exhibits some regular variation properties, and we investigate th...