نتایج جستجو برای: dopamine
تعداد نتایج: 45248 فیلتر نتایج به سال:
Dopamine (DA) plays a crucial role in the functioning of human central nervous system, participating both physiological and psychological processes. It is an important research topic biomedical science. However, we need to constantly monitor concentration dopamine body, sensors required for this usually require good sensitivity order achieve fast accurate measurements. In project, CeO2 CuCrO2 c...
To examine the regulation of midbrain dopamine neurons, recordings were obtained from single neurons of freely moving, genetically engineered dopamine-deficient (DD) mice. DD mice were tested without dopamine signaling (basal state) and with endogenous dopamine signaling (after L-dopa administration). In the basal state, when dopamine concentration in DD mice is <1% of that in control animals, ...
Developing a convenient detection method for dopamine holds significant incentive due to its high clinical significance. Herein, we synthesize crystalline MnOOH nanowires (MNWs) via simple solvothermal treatment of KMnO4 and demonstrate that they possess excellent oxidase-like activity owing the presence pure Mn3+ sites on MNWs. Particularly, MNWs catalyze rapid oxidation into aminochromes, whi...
Pharmacologic approaches that diminish dopamine-mediated neural transmission in brain have antipsychotic actions in humans. Blockade of D2 family dopamine receptors is the most common strategy. A paradoxical strategy of using dopamine agonists in particular circumstances to similarly diminish dopaminergic transmission is based on the known function of dopamine autoreceptors and on consideration...
The molecular dynamics and density functional theory (DFT) can be applied to discriminate electrocatalyst’s electron transfer (ET) properties. It will interesting the ET properties of green electrocatalysts such as amino acids. Here, we have used DFT compare electrocatalytic abilities asparagine glutamine at carbon paste electrode interface. Cyclic voltammetric results reveal that activities as...
The reinforcing effects of abused drugs are mediated by their ability to elevate nucleus accumbens dopamine. Amphetamine (AMPH) was historically thought to increase dopamine by an action potential-independent, non-exocytotic type of release called efflux, involving reversal of dopamine transporter function and driven by vesicular dopamine depletion. Growing evidence suggests that AMPH also acts...
Dopamine transporter deficiency syndrome due to SLC6A3 mutations is the first inherited dopamine 'transportopathy' to be described, with a classical presentation of early infantile-onset progressive parkinsonism dystonia. In this study we have identified a new cohort of patients with dopamine transporter deficiency syndrome, including, most significantly, atypical presentation later in childhoo...
Preferential enhancement of dopamine transmission within the nucleus accumbens (NAc) shell is a fundamental aspect of the neural regulation of cocaine reward. Despite its importance, the nature of this effect is poorly understood. Here, we used fast-scan cyclic voltammetry to examine specific transmission processes underlying cocaine-evoked increases in dopamine transmission within the NAc core...
Drugs of abuse hijack brain-reward circuitry during the addiction process by augmenting action potential-dependent phasic dopamine release events associated with learning and goal-directed behavior. One prominent exception to this notion would appear to be amphetamine (AMPH) and related analogs, which are proposed instead to disrupt normal patterns of dopamine neurotransmission by depleting ves...
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