Objective To evaluate the effects of deep brain stimulation subthalamic nucleus (STN-DBS) on motor complications in patients with Parkinson disease (PD) beyond 15 years after surgery. Methods Data complications, quality life (QoL), activities daily living, Unified Parkinson’s Disease Rating Scale scores, dopaminergic treatment, measures, and side STN-DBS were retrospectively retrieved compared ...

Testing the clinical efficacy of drugs that also have important side effects on locomotion needs to be properly designed in order to avoid erroneous identification of positive effects when the evaluation depends on motor-related tests. One such example is the evaluation of analgesic role of drugs that act on dopaminergic receptors, since the pain perception tests used in animal models are based...

Parkinson's disease (PD) is the second most important age-related neurodegenerative disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from 41 per 100,000 in the fourth decade of life to over 1900 per 100,000 in people over 80 years of age. As a movement disorder, the PD phenotype is characterized by rigidity, resting tremor, and bradykinesia. Parkinson's dise...

Parkinson’s disease is the commonest neurodegenerative condition, which can be eased for a long while, however, it inevitably leads to patients’ death. Dying with problematic as clinical situation may change dynamically and necessitate frequent drug dose changes introduction of new, preferably injectable, drugs necessary. Current treatment aims increase brain’s dopamine focusing mainly on motor...

introduction: dopamine plays an important role in the central nervous system for modulating food intake. dopamine receptors are distributed within the hypothalamus, and expression of d1 receptors is significant in hypothalamic paraventricular nucleus (pvn). therefore, the aim of this study was to find if pvn-microinjected skf38393, d1 receptor agonist, may modulate food intake. methods: guide c...

Working memory is a limited capacity system that integrates and manipulates information across brief periods of time, engaging a network of prefrontal, parietal and subcortical brain regions. Genetic control of these heritable brain processes have been suggested by functional genetic variations influencing dopamine signalling, which affect prefrontal activity during complex working memory tasks...