Retinoblastoma patients have a strongly increased risk of second malignancies, and survivors with a third or subsequent malignancy are increasingly observed. However, it has not been examined whether survivors who developed a second malignancy have a greater risk of a subsequent malignancy. On the basis of the Dutch retinoblastoma registry, the risk of a third malignancy was compared with cance...

background recommendations to immunize healthcare workers (hcws) against hepatitis b are well known. however, a proportion of individuals do not respond to the primary standard three-dose hb vaccination schedule. conclusions both the single- and double-dose hb vaccines were adequately immunogenic, and the double-dose hb vaccine was not significantly more immunogenic than the single-dose vaccine...

BACKGROUND AND AIMS Primary gastric B-cell lymphoma is the second most common malignancy of the stomach. There are many controversial issues about its diagnosis, treatment and clinical management. "Double-hit" and "double-protein" involving gene rearrangement and protein expression of c-Myc and bcl2/bcl6 are the most used terms to describe DLBCL poor prognostic factors in recent years. However,...

OBJECTIVE We noticed that a significant proportion of our patients with head and neck mucoepidermoid carcinoma (HNMEC) had second primary malignancies. To our knowledge, such an association has never been described. The aim of our study is to elucidate the association between second primary malignancies and HNMEC. STUDY DESIGN Case series with chart review. SETTING Tertiary referral center....

  Primary non-Hodgkin lymphoma of liver is a very rare malignancy. Here we report a case of primary hepatic Burkitt’s lymphoma in a 34-year old man who was known case of acquired immunodeficiency syndrome (AIDS) and presented with weight loss, abdominal pain, and fever. Positive laboratory findings were mild anemia and elevated levels of lactate dehydrogenase (LDH) and alkaline phosphatase (AL...

BACKGROUND Thyroid cancer is one of the most common secondary cancers after treatment of malignancy in childhood or adolescence. Thyroid gland is very sensitive to the carcinogenic effect of ionizing radiation, especially in children. Imbalance between pro- and anti-oxidant factors may play a role in thyroid carcinogenesis. Our study aimed to assess the relationship between genetic variability ...

second primary malignancy following multiple myeloma (mm) was reported several years ago. there are also rare reports of cases with synchronous mm and other malignancies. to our knowledge, only one case of mm following bladder cancer has been reported in the literature. here, we report the second case occurred three months after diagnosis of bladder cancer.

Aortoenteric fistulae are rare but potentially catastrophic entities that can affect either a diseased or reconstructed abdominal aorta and therefore they are classified as pr imary or secondary fistulae. The subtleties of its presentation, lack of specific diagnostic tests, delay in therapy and lack of consensus on the optimal operative t reatment have contributed to the high morbidi ty and mo...

Sister Mary Joseph's nodule is sometimes the first sign of an internal malignancy, including gastrointestinal, gynecological, or malignancy of unknown primary. It is rarely the sole presentation of a primary peritoneal cancer. In this report, we present the case of a 70-year-old female with umbilical drainage and a computed tomography scan consistent with solitary umbilical nodule. Excision of ...

BACKGROUND Primary retroperitoneal mucinous cystadenoma of borderline malignancy represents a rare tumor, with unclear histogenesis, concerning almost exclusively women. Only two cases concerning male patients have been reported. CASE REPORT We herein report a case of a 37 year old man undergone laparotomy for a sizable retroperitoneal tumor resulting after the histological examination to a p...