the protective effect of tomato extract and lycopene on acute doxorubicin-induced myocardial toxicity was evaluated in mice. doxorubicin toxicity, induced by a single intraperitoneal injection (15 mg/kg), was revealed by elevated serum cpkmb and histopathological observations. tomato extract (1.2 and 2.4 g/kg, i.p.) and lycopene (1.7 and 3.5 mg/kg, i.p.), prevented the rise in serum cpkmb and a...

Daunorubicin (Cerubidin) No No No No Dacarbazine (DTIC) Yes No No No Vindesine (Eldisine) Yes No No No 5-Fluorouracil (Fluoro-uracil) No No No No Mithramycin (Mithracin) No No No No Mitomvcin (mitomycin C, Kyowa) No No No No Mustine hydrochloride (Mustine) Yes No No No CyclophosphaITiide (Endoxan-Asta) No No No No Doxorubicin (Adriamycin) Yes No Yes Yes Cytarabine (Cytosar-U) No No No No Actino...

In this study, a novel UV-responsive drug carrier based on mesoporous silica nanoparticles (MSNs) has been designed. A 'self' peptide was introduced onto the MSN surface through a supramolecular photoswitchable heteroternary complexation of cucurbit[8]uril, azobenzene and 4,4'-dipyridyl derivative. The light-induced isomerization of azobenzene contributed to the formation of intelligent cucurbi...

Here, a double-strand (ds) DNA microarray-based fluorescence assay has been deployed for studying endonuclease functionality and inhibition. The dsDNA microarrays are fabricated by hybridization of the Cy5-labeled oligonucleotides with the immobilized complementary oligonucleotide probes on the glass slide. The microarray displays significant fluorescence decrease in response to endonuclease, w...

Mantle cell lymphoma is molecularly characterized by the chromosomal translocation t(11;14) (q13;q32) that results in a constitutional overexpression of the cell cycle regulator protein cyclin D1. Generally, the disease is characterized by rapid relapses and poor long-term outcome. However, a subset of patients with indolent disease has been identified. Randomized trials have demonstrated the s...

Antitumor anthracyclines such as doxorubicin and epirubicin are known to cause cardiotoxicity that correlates with anthracycline accumulation in the heart. The anthracycline amrubicin [(7S,9S)-9-acetyl-9-amino-7-[(2-deoxy-β-d-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-napthacenedione hydrochloride] has not shown cardiotoxicity in laboratory animals or patients in approv...

OBJECTIVE To assess the rate of objective response to pegylated liposomal doxorubicin hydrochloride (Caelyx) in patients with advanced or refractory cutaneous T-cell lymphoma (CTCL). DESIGN Prospective, open, multicenter study. SETTING Thirteen dermatology departments in France. PATIENTS Twenty-five patients with either (1) stage II to stage IV CTCL previously unsuccessfully treated with ...

The paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of trabectedin for the treatment of relapsed platinum-sensitive ovarian cancer, based upon a review of the manufacturer's submission to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal process. The submission add...

background: dilated cardiomyopathy is associated with a progressive deterioration in cardiac function and eventually death. initial interest in this hypothesis was to create another large animal model for dilated cardiomyopathy in addition to pigs and dogs . methods: after the induction of anesthesia to 10 female sheep, a carotid-jugular shunt was created in all the animals via a 1-cm fistula b...