Hyperuricemia is present in approximately 5% of the population, the vast majority of whom are asymptomatic and at no clinical risk. Complications, including renal calculi, uric acid nephropathy and gout, occur in a small proportion of patients. Allopurinol, an analog of hypoxanthine, has been widely used in clinical practice for over 30 years for the treatment of hyperuricemia and gout. Two per...

Low-molecular-weight heparins are widely used for the prophylaxis and treatment of venous thromboembolism. However, they can induce adverse skin reactions. The most common reactions are delayed-type hypersensitivity reactions at injection sites. Rare systemic reactions have been reported. We report, to our knowledge, the first case of a drug reaction with eosinophilia and systemic symptoms synd...

Drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DiHS/DRESS) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are severe drug eruptions characterized by contrasting clinical pictures. Sequential reactivations of several herpesviruses have exclusively been demonstrated in the former. It remains to be determined, however, why the sequent...

Résumé Le syndrome d'hypersensibilité médicamenteuse ou Drug Rash with Eosinophilia and Systemic Symptoms ou DRESS syndrome est une toxidermie grave qui peut mettre en jeu le pronostic vital. Il faut y penser devant toute réaction cutanée après la prise des médicaments. Nous rapportons un cas clinique d'un patient âgé de 45 ans traité pour tuberculose pulmonaire TPM+ présentant un DRESS syndrom...

This paper presents the version of the DRESS System that participated in the Blizzard Challenge 2008. Here we show a basic overview of the DRESS system, methodology and a description of its unit selection. We present a novel concept to increase the efficiency of the exhaustive speech unit search within the database by an unit selection model that is based on mapping analysis of the concatenatio...

Summary Drug reaction with eosinophilia and systemic symptoms (DRESS) describes a severe medication-induced adverse reaction, which has cutaneous, haematological and solid-organ features. It is one of the triad of life-threatening drug hypersensitivity dermatoses, along with acute generalized exanthematous pustulosis (AGEP) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). In t...

Method To investigate the types of liver injury and factors involved, including the chronology, recovery time, relationship with culprit drugs and the pathology correlations, a retrospective study was conducted by reviewing all medical records of DRESS patients diagnosed between Dec. 2000 and Jan. 2013 in the National Taiwan University Hospital Database. DRESS was defined according to the Inter...