The purpose of the present study was to formulate and evaluate donepezil loaded bio-nanoparticles for effective treatment of Alzheimer’s disease. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Carica papaya by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, ...

Introduction At a time when radio spectrum is a highly valued commodity and where environmental issues are high on the agenda of local planning authorities, it has become vital for network planners to determine the optimum network design to satisfy these demands. Accurately predicting propagation in highly cluttered environments, where local effects are dominant, is not a simple task. Using a m...

Since 1994 we are told to believe that software agents will become the next revolution in computer science [5]. This change is to occur not only in the ways we construct software [4] but it is also to have a much broader impact on the field of human-computer interaction [3,5]. Unfortunately, as it is easy to see, the revolution prophesized in 1994 does not seem to materialize (regardless of the...

Efficient high-throughput expression of genes in mammalian cells can facilitate large-scale functional genomic studies. Towards this aim, we developed a simple yet powerful method to deliver genes into cells by cationic polymers on the surface of substrates. Transfection can be achieved by directly contacting nucleic acid-cell mixtures with the cationic substrates, e.g. polyethylenimine/collage...

Drug-loaded hydrogels provide a means to deliver pharmaceutical agents specific sites within the body at controlled rate. The aim of this paper is understand how drug release can be achieved by tuning initial distribution molecules in hydrogel. A mathematical model presented for spherical drug-loaded captures nonlinear elasticity polymer network and thermodynamics swelling. By assuming that are...

The cover highlights an array of 3D-printed porous microneedles, fabricated by two-photon polymerization as described in the article number 2300161 Esraa Fakeih, Khaled N. Salama, and co-workers. Due to their multiple pores, these microneedles can deliver fluids large areas while still preserving mechanical stability. These be used healthcare applications, such transdermal drug delivery interst...