Cholangiocarcinoma is a predominantly fatal cancer, which can be difficult to treat. It has been reported that the administration of pioglitazone temporarily improved not only diabetic control, but also bile duct carcinoma-induced cholangiohepatitis. Pioglitazone is considered to have both direct and indirect mechanisms of action on the tumor-related hepatitis. Several molecules induced by thia...

800x600 background : hepatitis b and c infections have remained major global health burdens during the most recent century. the viral agents responsible for these diseases share common modes of transmission with human immunodeficiency virus (hiv) such as needle-sharing in iv drug abusers. coinfection of hepatitis b or c with hiv increases the rate of progression of chronic liver disease. given ...

Drug-induced liver injury (DILI) can be considered in cases of acute hepatitis by the exclusion any disease-related causes. For several decades, anabolic steroids have been not only as drugs for treatment diseases such hypogonadism, sarcopenia, hypotrophy cancer patients, aplastic anemia, etc., but also risk factor failure, that lead to cancer, and even sudden death. Anabolic are known increasi...

Isoniazid, pyrazinamide and rifampicin have hepatotoxic potential, and can lead to such reactions during antituberculosis chemotherapy. Most of the hepatotoxic reactions are dose-related; some are, however, caused by drug hypersensitivity. The immunogenetics of antituberculosis drug-induced hepatotoxicity, especially inclusive of acetylaor phenotype polymorphism, have been increasingly unravell...

Hepatitis E virus (HEV) genotype 3 is endemic in the United Kingdom but the complete sequence of HEV, generated directly from a clinical sample, is lacking. We report a near full-length genome sequence of genotype 3 HEV from the serum of a patient with acute hepatitis.

BACKGROUND Cases of acute hepatitis C virus (HCV) have been rising across the United States, and southwest Ohio is no exception. OBJECTIVES To describe the rise in cases of HCV in our region, the Ohio Disease Reporting System was reviewed for all cases of positive HCV testing from 2010 through August 2015. METHODS 29,018 cases were reviewed, with 18,678 (64.4%) cases included in the final a...

Hepatitis E virus (HEV) is responsible for large waterborne epidemics of acute hepatitis in endemic regions and for sporadic autochthonous cases in non endemic regions. Although the water vector has been thoroughly documented in endemic regions, very little is known about the modes of contamination occurring in non endemic regions. Unlike the other hepatitis viruses, HEV has an animal reservoir...