The main function of a pavement is to distribute the traffic-induced load over its different layers. While flexible design methods are based on linear elastic calculation, real behavior layers highly non-linear and elastic. They can also, in some cases, be plastic viscous. This research aims develop three-dimensional numerical model that closely similar test FWTT conditions. will have geometry ...

In an attempt to de®ne clinically relevant models of akinesia and dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, we have examined the effects of drugs with high (L-DOPA) vs. low (bromocriptine) dyskinesiogenic potential in Parkinson's disease on three types of motor performance, namely: (i) abnormal involuntary movements (AIMs) (ii) rotational behaviour, and (iii) spontaneous forelimb ...

In an attempt to define clinically relevant models of akinesia and dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, we have examined the effects of drugs with high (L-DOPA) vs. low (bromocriptine) dyskinesiogenic potential in Parkinson's disease on three types of motor performance, namely: (i) abnormal involuntary movements (AIMs) (ii) rotational behaviour, and (iii) spontaneous forelimb...

hydrophobic grade fumed silicas are generally used in tabletting as lubricants. they are also found to retard the release of pharmaceutical actives. this is because of their hydrophobic nature, which gives good cohesive and adhesive properties. considering this point it was thought that they could be used as dry coating agents for solid dosages forms. the model drug selected for this work was p...

INTRODUCTION AND OBJECTIVES Left ventricular torsion decreases during transmural myocardial ischemia, but the effect of exercise on left ventricular torsion has not been widely studied. We hypothesized that exercise-induced ischemia may impair left ventricular torsion. Therefore, our aim was to study the effects of exercise on left ventricular torsion in patients with an ischemic response to ex...

This study compares the behavioural efficiency of dopaminergic mesencephalic neurons implanted into the rat neostriatum and/or the nucleus accumbens. The dopaminergic mesotelencephalic pathway was unilaterally destroyed by injection of 6-hydroxydopamine into the medial forebrain bundle at the level of the lateral hypothalamus. Three weeks later, embryonic dopaminergic mesencephalic neurons were...

BACKGROUND AND PURPOSE Predicting the risk of drug-induced adverse psychiatric effects is important but currently not possible in non-human species. We investigated whether the affective bias test (ABT) could provide a preclinical method with translational and predictive validity. EXPERIMENTAL APPROACH The ABT is a bowl-digging task, which quantifies biases associated with learning and memory...

It has been shown that pre-test systemic administration of morphine was able to reverse memory impairment induced by pre- or post-training morphine in an inhibitory avoidance paradigm. Since the recall of the learned information is possible only if the subject is in the same state as during the encoding phase, this kind of learning is known as state-dependent learning. Several drugs have been d...