As encapsulation of hydrophilic drugs in the solid lipid nanoparticles (SLNs) is still a challenging issue, the aim of this study was to prepare SLNs containing tramadol hydrochloride as a hydrophilic compound.The SLNs were prepared using glycerol monostearate (GMS), soy lecithin and tween 80 by double emulsification-solvent evaporation technique. The nanoparticles were optimized through a cent...

the present study deals with the formulation and evaluation of chitosan nanoparticles containing donepezil hydrochloride for the targeted delivery to the brain. nanoparticles were prepared by ionic gelation method using sodium tripolyphos-phate (tpp) as a cross linking agent followed by sonication. nanoparticles were obtained in the average size ranging from 116.8 to 227.5 nm. particle morpholo...

In this study, new antimicrobial hydrogels were prepared via reaction of functionalized-tragacanthgum (TG) biopolymer by quaternary ammonium functionalization of TG (QTG) with acrylic acid(AA). Characterization of the QTG hydrogels (QTG-AA) was carried out by FTIR,thermogravimetric analysis (TGA), and 1H NMR. Dynamic mechanical analysis, (DMA) wasconducted to characteriz...

An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

background microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. the microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. acetone/paraffin systems are conventionally used. objectives the current study aimed to investigate two diffe...

objectives: postsurgical adhesion is one of the common complications after surgery. some anti-adhesion barriers are commercially available which are not customary used by physicians as much as expected because of ineffectiveness. recently, nanofibers have been introduced as anti-adhesion barriers with the potential of drug delivery. in the light of role of inflammation and oxidative stress in a...

An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

in the present study, sodium alginate microparticle for oral delivery of furosemide was designed whether the encapsulation into microparticles might improve the oral absorption of this potent loop diuretic. we described preparation of microspheres based on ionotropic gelation method and characterized its physicochemical properties. to acquire an optimum formulation, a generalized regression neu...