نتایج جستجو برای: drug resistancsequence homology
تعداد نتایج: 635775 فیلتر نتایج به سال:
Understanding of multidrug binding at the atomic level would facilitate drug design and strategies to modulate drug metabolism, including drug transport, oxidation, and conjugation. Therefore we explored the mechanism of promiscuous binding of small molecules by studying the ligand binding domain, the PAS-B domain of the aryl hydrocarbon receptor (AhR). Because of the low sequence identities of...
Inspired by work of Lipshitz-Sarkar, we show that the module structure on link Floer homology detects split links. Using results Ni, Alishahi-Lipshitz, and establish an analogous detection result for sutured homology.
A gene is considered essential if its function indispensable for the viability or reproductive success of a cell an organism. Distinguishing genes from non-essential ones fundamental question in genetics, and it key to understanding minimal set functional requirements Knowledge also crucial drug discovery. Several reports literature show that location protein-protein interaction network correla...
The human kinome is one of the most productive classes of drug target, and there is emerging necessity for treating complex diseases by means of polypharmacology (multi-target drugs and combination products). However, the advantages of the multi-target drugs and the combination products are still under debate. A comparative analysis between FDA approved multi-target drugs and combination produc...
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