The present research was aimed to develop and characterize a sustained release dry powder inhalable formulation of salbutamol sulphate. The salbutamol sulphate microparticles were prepared by solvent evaporation method using biodegradable polymer poly (D,L-lactic-co-glycolic acid) to produce salbutamol sulphate microparticle mixed with carrier respirable grade lactose for oral inhalation of dry...

OBJECTIVE To verify the efficacy, side effects, and cost of treatment of acute asthma attacks, using different inhaler devices. METHODS This is a randomized, double-blind, placebo-controlled study. Salbutamol was administered via a nebulizer, a metered-dose inhaler (attached to a commercially available spacer device), a homemade non-valved spacer device, or a dry powder inhaler. Assessments w...

CONTEXT Budesonide is an inhaled corticosteroid with high topical potency and low systemic activity recommended in the treatment of chronic asthma. OBJECTIVE This study was conducted to determine the efficacy and safety of inhaled budesonide via a breath-activated, multi-dose, dry-powder inhaler. TYPE OF STUDY Multicenter randomized parallel-group, placebo-controlled, double-blind, clinical...

Fourteen Solanum cultivars (S. aculeatissimum, S. melongena, S. torvum, S. trilobatum, S. stramonifolium, S. mammosum and S. wrightii) and fourteen Capsicum cultivars (C. annuum, C. frutescens and C. minimum) cultivated in Thailand were determined their total phenolic contents in term of gallic acid (g) per 100 g of crude extract and per 100 g of dry herb powder. The total phenolic content of S...

Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method (DEM), which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criter...

BACKGROUND Therapeutic inhaled aerosols are often delivered to spontaneously breathing tracheostomized children. Although aerosol delivery can be affected by several factors, no recommendations for device/drug formulation choice are available. We hypothesized that practice modalities will vary among different institutions. METHODS The respiratory care departments in institutions in the Unite...

  Six different diets including two rainbow trout starters, Gammarus dry powder, shrimp dry powder, egg yolk dry powder and newly hatched Artemia were used in feeding of Caspian Kutum larvae. During a 4-week trial, larvae with a mean weight of 17.5 ± 4.7 mg were fed with three replicates and growth parameters were measured at the end of the experiment. Thirty fish in each experimental unit with...

Purpose: This study determined total surface energy distributions using an Inverse Gas Chromatography (IGC) to understand the de-agglomeration of fine lactose powders commonly used in dry powder inhaler formulations. Methods: The particle size distribution (PSD) of two lactose samples, Lactohale 300 (Lac A) and micronized lactose (Lac B), were determined by laser diffraction in liquid media, an...

AIM The purpose of this pilot study was to identify the subsurface enamel demineralising potential of two possible acidogenic lactose-based powders and their corresponding generic pump inhalers. METHODS Ten healthy non-asthmatic adults participated in a 5- leg randomised crossover study including a 10% sucrose control. A twice-daily 400 microg dose of inhaler was applied in vitro to a deminer...

  Six different diets including two rainbow trout starters, Gammarus dry powder, shrimp dry powder, egg yolk dry powder and newly hatched Artemia were used in feeding of Caspian Kutum larvae. During a 4-week trial, larvae with a mean weight of 17.5 ± 4.7 mg were fed with three replicates and growth parameters were measured at the end of the experiment. Thirty fish in each experimental unit with...