Abstract Internalization and intracellular trafficking of G protein-coupled receptors (GPCRs) play pivotal roles in cell responsiveness. Dysregulation receptor can lead to aberrant signaling behavior. Here, using an endosomal BRET-based assay a high-throughput screen with the prototypical GPCR angiotensin II type 1 (AT1R), we sought identify inhibitors from library ~115,000 small molecules. We ...

introduction: alloimmunization is a reaction of the immune system to foreign antigens. for prevention of alloantibody formation, performing of type and screen test is necessary on a patient's blood specimen as part of pre-transfusion testing. materials and method: in this cross-sectional study, type and screen test done for 1420 patients with elective surgery for detection of alloantibody in im...

Tiling multiple monitors to increase the amount of screen space has become an area of great interest to researchers. While previous research has shown user performance benefits when tiling multiple monitors, little research has analyzed whether much larger high-resolution displays result in better user performance. We compared user performance time, accuracy, and mental workload on multi-scale ...

In this paper, the preparation of a potentiometric strip for pH monitoring in saliva samples is reported. The potentiometric strip consists of a solid contact pH-selective and of a solidcontact ionogel reference electrode prepared on a dual screen printed substrate. The screen printing protocols, i.e., type of inks and number of deposits, were adjusted to relatively improve the batch reproducib...

the use of mammography film-screen is limited in general radiography. the purpose of this study was to compare the effectiveness of mammographic film-screen and standard film-screen systems in the detection of small bone fractures. radiographs were taken from patients' extremities and neck areas using mammography film-screen and standard film-screen (n=57 each). fourteen other radiographs were ...

OBJECTIVES The present study used qualitative methods to: (1) examine the strategies that were used by parents of children aged 5-6 years to manage screen viewing; (2) identify key factors that affect the implementation of the strategies and (3) develop suggestions for future intervention content. DESIGN Telephone interviews were conducted with parents of children aged 5-6 years participating...

The topic of data warehousing encompasses architec-tures, algorithms, and tools for bringing together selected data from multiple databases or other information sources into a single repository, called a data warehouse , suitable for direct querying or analysis. In recent years data warehousing has become a prominent buz-zword in the database industry, but attention from the database research c...