Sepsis remains a major medical challenge, for which, apart from improvements in supportive care, treatment has not relevantly changed over the last few decades. Vasodilation and vascular leakage play a pivotal role in the development of septic shock, with vascular leakage being caused by disrupted endothelial integrity. Adrenomedullin (ADM), a free circulating peptide involved in regulation of ...

BACKGROUND Current cost data on tissue expansion followed by exchange for permanent implant (TE/I) reconstruction lack a necessary assessment of the experience of a heterogenous breast cancer patient population and their multiple outcome pathways. We extend our previous analysis to that of direct hospital cost as bundling of payments is likely to follow the changing centralization of cancer car...

Neutral and negatively charged liposomes containing Adria mycin (ADM) were examined for the efficiency of drug entrap ment, serum stability, in vivo tissue distribution, and tumorinhibitory activity. Entrapment of ADM in negatively charged liposomes containing phosphatidylserine (PS) or cardiolipin (DPG) was 3to 4-fold higher than in neutral phosphatidylcholine (PC) liposomes with or without ch...

AIM Adrenomedullin (ADM) has been shown to protect the heart against ischaemic injury, but little is known of the underlying mechanism. Mitochondrial Ca(2+)-activated K(+) (mitoK(Ca)) channels play a key role in cardioprotection. This study examined whether mitoK(Ca) channel is involved in the protection afforded by ADM. METHODS Flavoprotein fluorescence in rabbit ventricular myocytes was mea...

In this Letter we propose a robust quantum repeater architecture building on the original Duan-Lukin-Cirac-Zoller (DLCZ) protocol [L.-M. Duan, M. D. Lukin, J. I. Cirac, and P. Zoller, Nature (London) 414, 413 (2001)10.1038/35106500]. The architecture is based on two-photon Hong-Ou-Mandel-type interference which relaxes the long-distance stability requirements by about 7 orders of magnitude, fro...

We previously reported that MX2, a new morpholino anthracycline, showed marked effects on pleiotropic drug-resistant sublines of murine P388 leukemia in vivo as well as in vitro. In this study we examine the in vitro cytotoxicity against pleiotropic drug-resistant sublines of human tumor cell lines. MX2 was effective against multidrug-resistant sublines of four human tumor cell lines; these cel...

We previously reported that M\2, a new morpholino anthracycline, showed marked effects on pleiotropic drug-resistant sublines of murine P388 leukemia in vivo as well as in vitro. In this study we examine the in vitro cytotoxicity against pleiotropic drug-resistant sublines of human tumor cell lines. MX2 was effective against multidrug-resistant sublines of four human tumor cell lines; these cel...

—The effect of water temperature on the efficacy of hydrogen peroxide (H2O2) as a disinfectant for channel catfish Ictalurus punctatus eggs was examined at 248C and 288C. Eggs at each temperature were treated with H2O2 at 0, 100, 250, 500, or 1,000 mg/L as a daily 15-min bath. Mean hatching success at 248C was greatest (P . 0.05) for eggs treated with 250 and 500 mg/L H2O2, hatching success ten...

OBJECTIVE Urocortin 1 (UCN1) has vasodilator, diuretic, and natriuretic effects, and its expression increases in heart failure (HF). Adrenomedullin (ADM) increases cardiac output and lowers blood pressure in healthy men and in patients with heart failure. The aim of the study was to determine UCN1 and ADM levels in patients with HF, to evaluate the relationship of UCN1 and ADM with various clin...