Bleeding from a proved or probable stomal ulcer at some time after an operation for peptic ulceration often seems to be preceded by haemorrhage from the original, usually duodenal, ulcer. This association has been noted in the past (Hurst and Stewart, 1929; Donaldson, Handy, and Papper, 1958), but satisfactory evidence in its favour is lacking. The case histories of patients admitted to the Cen...

Experimental and clinical data have incriminated excess gastric acid secretion as an important factor in the development of duodenal ulcer. On the other hand, gastric ulcer is characteristically associated with normal to low levels of acid secretion, and mucosal resistance factors have been invoked to explain the pathogenesis. The purpose of this report is to summarize the evidence favouring th...

There is a new model of chronic duodenal ulcer in which the ulcer is generated by irradiating the lower mediastinum of mice with a single dose of 18 Gy 250 kV x rays. Single ulcers develop in the proximal duodenum of about half the animals. Previous studies have shown a remarkable morphological and behavioural similarity to duodenal ulcer in man. Ulceration occurs because of an imbalance betwee...

BACKGROUND It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS The association between peptic ulcer and gastric cancer was studied among patients followed ...

Six of 25 renal transplant recipients had a duodenal ulcer at endoscopy. Histamine concentration and the activity of histamine methyltransferase, the degrading enzyme of histamine, were measured in gastric mucosal biopsies obtained at endoscopy and compared with patients with duodenal ulcer but not undergoing transplant and with patients with an apparently normal stomach and duodenum. Histamine...