Transcription occurs in stochastic bursts. Early models based upon RNA hybridisation studies suggest bursting dynamics arise from alternating inactive and permissive states. Here we investigate bursting mechanism in live cells by quantitative imaging of actin gene transcription, combined with molecular genetics, stochastic simulation and probabilistic modelling. In contrast to early models, our...

Graph transformation can be used to implement stochastic simulation of dynamic systems based on semi-Markov processes, extending the standard approach based on Markov chains. The result is a discrete event system, where states are graphs, and events are rule matches associated to general distributions, rather than just exponential ones. We present an extension of this model, by introducing a hi...

The copyright law of the United States (title 17, U.S. Code) governs the making of photocopies or other reproductions of copyrighted material. Any copying of this document without permission of its author may be prohibited by law. Abstract The research described in this paper is motivated by the complexity surrounding the development of decision support systems (DSSs) for collaborative design p...

To enable secure and efficient dynamic spectrum sharing (DSS) with guaranteed revenue quality of service (QoS) in future wireless communications, we present a consortium blockchain based DSS framework, where the regulators supervise whole process DSS, thus each participant can be guaranteed. Each mobile network operator (MNO) on chain adaptively act as provider or requestor their demand, resour...

The aim of the present study is to investigate the preventive effect of pioglitazone on colitis induced with dextran sulfate sodium (DSS) in rats. Twenty-four male Sprague-Dawley rats weighing 180-200 g were randomized into four groups. Rats of the 1st group received only saline and served as normal group. Colitis was induced in the remaining 3 groups by 1.5% DSS administered in drinking water ...

The classic Vickrey-Clarke-Groves (VCG) mechanism ensures incentive compatibility, i.e., that truth-telling of all agents is a dominant strategy, for a static one-shot game. However, in a dynamic environment that unfolds over time, the agents’ intertemporal payoffs depend on the expected future controls and payments, and a direct extension of the VCG mechanism is not sufficient to guarantee inc...

We consider an asset-liability management (ALM) problem for a defined benefit pension fund (PF). The PF manager is assumed to follow a maximal fund valuation problem facing an extended set of risk factors:  due to the longevity of the    PF members, the inflation affecting salaries in real terms and future incomes, interest rates and market factors affecting jointly the PF liability and asset p...

In this paper, to cope with the stochastic dynamic (or multi-period) problem, two new quadratic assignment-based mathematical models corresponding to the dynamic and static approaches are developed. The product demands are presumed to be dependent uncertain variables with normal distribution having known expectation, variance, and covariance that change from one period to the next one, randomly...

We study a stochastic control system, described by Ito’s controllable equation, and evaluate the solutions by an entropy functional (EF), defined by the equation’s functions of controllable drift and diffusion. Considering a control problem for this functional, we solve the EF control’s variation problem (VP), which leads to both a dynamic approximation of the process’ entropy functional by an ...

Health organizations are complex to manage due to their dynamic processes and distributed hospital organization. It is therefore necessary for healthcare institutions to focus on this issue to deal with patients' requirements. We aim in this paper to develop and implement a management decision support system (DSS) that can help physicians to better manage their organization and anticipate the f...