Acanthamoeba keratitis (AK) is a sight-threatening infection of the cornea disease that often presents with a lengthy and not fully effective treatment. Current therapeutic options against Acanthamoeba are not very effective against the cyst. Calibrated trophozoite/cyst suspension was incubated with the same volume of serial dilutions of the Trigonella foenum graecum aqueous extract (200, 250, ...

Studies were conducted to determine whether intestinal cellulolytic bacteria could be introduced into the bovine rumen or pig large intestine. In the first study, the ruminal fluid of three cows was evacuated and replaced with 20 liters of buffer and 6 liters of the ruminal or swine cellulolytic organism Clostridium longisporum or Clostridium herbivorans, respectively. The introduced organisms ...

Adverse reactions to iron dextran are usually delayed and consist of joint pain, vomiting, nausea, headache, and fever. Lifethreatening reactions to iron dextran have been reported [1,2]. We report the case of a 48-year-old woman who experienced a severe reaction to iron dextran and who was able to receive the drug after undergoing a series of tolerance induction protocols. The patient had celi...

The pharmacokinetic properties of mezlocillin were evaluated in newborn infants. Mean peak and trough concentrations of drug in plasma, after 75 mg of mezlocillin per kg given intravenously, were 252 and 72 micrograms/ml, respectively, in infants who were less than 38 weeks gestation and less than or equal to 7 days old, compared with 139 and 9 micrograms/ml, respectively, in infants greater th...

Dr. Colmar Niederstadt, Department of Internal Medicine, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck (Germany) From days 4-18 after intoxication, we repeatedly measured the urinary concentration of immunoglobulin G, albumin, < xi-microglobulin and endogenous creatinine clearance (fig. 1). Ethylene glycol itself is probably not nephrotoxic, but in the metabolism of ethyle...

Alginate (an extract from seaweed e.g. Sargassum fluitans) that finds applications largely in nanotechnology, industrial/pharmaceutical processes have not been produced locally. fluitans harvested Agbama Sea, Andoni, Rivers State was dried, ground and reacted with CaCl2 (3.02g) 300 ml of deionized water. The mixture allowed to stand for 24 h before filtration the residue 1 % HCl 100 distilled w...

Human monocytic cell line THP-1 incubated with as little as 10 ng/ml of phorbol myristate acetate bound and metabolized 1-2 micrograms of Ac-LDL over a 5-h period. In the absence of phorbol treatment, no specific metabolism of Ac-LDL occurred. Optimal levels of receptor were reached after 72 h of exposure. Induction of receptor was dependent on protein and RNA synthesis and was partially revers...

photodynamic therapy (pdt) using 5-aminolevulinic acid (5-ala)-induced protoporphyrin ix (ppix) has been considered as a new method for treating neoplasms. however, ala-pdt is suboptimal for thick tumors. searching for new approaches, we investigated the effect of adding differentiation therapy (dt) with vitamin e succinate (ves) to pdt in human prostate ln-cap-fgc10 cancer cells in vitro . the...

Desenvolveu-se uma metodologia de análise por injeção sequencial (SIA) para a determinação fluorimétrica de quinino em refrigerantes. Dispersão mínima e mistura eficiente foram obtidas aspirando-se 200 mL de amostra entre duas zonas de 100 mL de reagente (0,10 mol L H2SO4) a uma vazão de 250 mL s, usando uma bobina de reação de 50 cm de comprimento (0,8 mm de diâmetro interno). Resposta linear ...