The murine Pax-3 protein contains two DNA-binding domains, a paired domain and a homeodomain, and alterations in the Pax-3 gene are responsible for the neural tube defects observed in the Splotch (Sp) mouse mutant. Of five Sp alleles, Splotch-delayed (Spd) is the only one that encodes a full-length Pax-3 protein, containing a single glycine-to-arginine substitution within the paired domain. To ...

This article presents the project «Towards a Joint Construction of Future Scenarios Basque». The had two aims: to help shape new phase pro-Basque move-ment for next decades, and design interpretative framework comprehend develop revitalization process Basque. We will describe theoretical methodological basis framework, which we have named KOHiKoGa Model (acronym development linguistic community...

We have isolated three radiosensitive mutants (V-C4, V-E5, and V-G8) of the Chinese hamster V79 cell line which also show increased sensitivities to killing by bleomycin (approximately 2-5-fold) and ethyl methanesulfonate (approximately 2-fold). Genetic complementation analysis indicates that all three mutants belong to one complementation group. The mutants show a radioresistant DNA synthesis ...

We show that addition of SR proteins to in vitro splicing extracts results in a significant increase in assembly of the earliest prespliceosomal complex E and a corresponding decrease in assembly of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex H. In addition, SR proteins promote formation of the E5' and E3' complexes that assemble on RNAs containing only 5' and 3' splice sites, r...

We have isolated nine putative odorant receptor genes from the chick, named COR1 to COR9, that belong to the large multigene family of olfactory G protein-coupled receptors found in the fish, rat, mouse, dog, and human. By combining genomic DNA blot analysis, low stringency library screenings, and several PCR analyses, we were able to detect approximately 20 COR genes in the chick genome highly...

The coast of Chile has been exposed to marine submersion events from storm surges, tsunamis and flooding due heavy rains. We present evidence these using sedimentary records that cover the last 1000 years in Pachingo wetland. Two sediment cores were analyzed for granulometry, XRF, pollen, diatoms TOC. Three extreme produced by three pluvial during El Niño episodes identified. Geochronology was ...

Poxviruses are large cytoplasmic DNA viruses. Vaccinia virus is a replication-competent prototypical poxvirus that causes mortality in the murine intranasal infection model, surrogate for smallpox infection. Modified vaccinia Ankara (MVA) highly attenuated strain replication-incompetent and safe vaccine against smallpox. The sensor cyclic GMP-AMP synthase cGAS plays an important role host antiv...

Bu çalışmada iki yerel diatomit toprağı preparatının (Detech® ve Demite®) tek başına bunların kokusuz sarımsak tozuyla belli oranlardaki karışımlarının Kırma Biti, Tribolium confusum du Val. Coleoptera: Tenebrionidae)’ne karşı etkinliklerinin belirlenmesi amaçlanmıştır. amaçla buğday üzerinde 25±1 ˚C sıcaklık % 65±5 nispi nem ortamında topraklarının 600, 900 1500 ppm (mg DE/kg ürün) konsantrasy...

In this study, we report that the treatment of strychinine (STR), an inhibitor of glycine receptor, induced premature onset of programmed cell death (PCD) of developing chick motoneurons (MNs). Treatment of STR on E4 chick embryo increased the apoptosis of MN on E5 when MN PCD does not occur normally. On the other hand, treatment of STR from E3 or E5 for 24 hours did not significantly influence...

Cofacial bimetallic tin(ii) ([Sn2(mBDCA-5t)]2-, 1) and lead(ii) ([Pb2(mBDCA-5t)]2-, 2) complexes have been prepared by hexadeprotonation of hexacarboxamide cryptand mBDCA-5t-H6 together with double Sn(ii) or Pb(ii) insertion. Reaction of 1 with elemental sulfur or selenium generates di-tin polychalcogenide complexes containing μ-E and bridging μ-E5 ligands where E = S or Se, and the Sn(ii) cent...