The aim of this study was to assess the efficacy and tolerability of the aqueous extract of Echium amoenum in combination with SSRIs in patients with General Anxiety Disorder (GAD). The study was an 8-week double-blind randomized clinical trial. Thirty-seven adult outpatients who met the DSM-IV-TR criteria for GAD based on the structured clinical interview participated in the trial. In this stu...

Putative activity of hydroalcoholic and aqueous infusion extracts of Echium amoenum L. was investigated in mice using the rotarod model of motor coordination and the elevated plus maze model of anxiety. The extracts were administered intraperitonealy (i.p.) once, one hour before performing the tests. Preliminary phytochemical study of the plant, with standard procedures, showed that it contains...