In this paper, we present a tile effect generation algorithm. The presented method cuts a given pictures with small-size tiles and an original image is composed of those tiles. The size of tiles is generated by random function. We use four parameters: size of horizontal and vertical block, size of skip blocks in horizontal and vertical direction. The presented method is tested on McM dataset. S...

1 Association of the British Pharmaceutical Industry. Guidelines on good clinical research practice. London: ABPI, 1988. 2 Kessler DA. The regulation of investigational drugs. N Engl3JMed 1989;320:281-8. 3 Committee on Proprietary Medicinal Products, EEC. Recommended basis for the conduct of clinical trials of medicinal products in the European Community. Brussels: EEC (in press). (Document III...

Additional Notes This note for guidance concerns the application of Part 4, section E of the Annex to Directive 75/318/EEC as amended and Article 4,2 point 8 of Directive 65/65/EEC as amended with a view to the granting of a marketing authorisation for a medicinal product. It defines when bioavailability or bioequivalence studies are necessary for immediate release products with a systemic effe...

Additional Notes This note for guidance is intended to facilitate the collection and submission of data to support applications for marketing authorisation within the EEC for polypeptide based products derived by rDNA technology and intended for medicinal use in man. It concerns the application of Part 2, sections A-E of the Annex to Directive 75/318/EEC as amended, with a view to the granting ...

BACKGROUND Cholesterol granuloma (CG) may involve the middle ear, the mastoid bone and the petrous apex. However, CG presenting as a mass obstructing the external ear canal (EEC) is relatively rare and it can be a diagnostic challenge. CASE PRESENTATION We report a case of a CG occupying the mastoid antrum and presenting as a mass into the EEC. Temporal bone computerized tomography showed a s...

The toxicity of elemental tungsten released from discharged shot was assessed against previous studies that established a 1% toxic threshold for soil organisms. Extremely heavy theoretical shot loadings of 69,000shot/ha were used to generate estimated environmental concentrations (EEC) for two brands of tungsten-based shot containing 51% and 95% tungsten. The corresponding tungsten EEC values w...

The enriched effect calculus (EEC) is an extension of Moggi’s computational metalanguage with a selection of primitives from linear logic. This paper explores the enriched effect calculus as a target language for continuation-passing-style (CPS) translations in which the typing of the translations enforces the linear usage of continuations. We first observe that established call-by-value and ca...