SUMMARY In the murine Ll2lO ascites tumor the resting stages were investigated on Days 5, 6, and 8 after transplantation of l0@ cells. The experimental work consisted of continuous labeling with thymidine-3 H combined with cytophotometric deter mination of the single-cell DNA content of unlabeled tumor cells. The present experimental data and earlier experiments with percentage of labeled mitos...

Previous studies in mice have shown tha t the incidence of metastases from intravenously injected tumor cells is influenced by various factors, such as the number of tumor cells injected and the sex of the host (8). Reports in the l i terature (6, 9, 18) indicate tha t the age of the host might also be a factor in the " t ake" of circulating tumor cell emboli. To determine the influence of age ...

The present investigation was undertaken to examine an evidence for the exchange diffusion of D-leucine as well as L-leucine and further to study the effect of temperature reduction on the exchange diffusion, in Ehrlich ascites tumor cells in vitro. The homoexchange diffusion for D-leucine was observed at 37 degrees C, the extent being nearly equal to that for L-leucine. The heteroexchange diff...

from the well-established observation that the protein bound carbohydrate level of blood plasma is elevated in cancerous individuals (28) and the possibility that cancer cells may contribute carbohydrate-containing proteins to the circulation (2, 3, 12, 13). For initial studies we have selected Ehrlich ascites carcinoma cells and are using glucosarnine-'4C to label carbohydrate-containing macro...

The photodynamic activity of dibiotinylated aluminum sulfophthalocyanine was studied in vitro and in vivo. Dibiotinylated aluminum sulfophthalocyanine provided enhanced phototoxic action on OAT-75 cell monolayers as compared with the parent drug. Photodynamic therapy of mice with Ehrlich carcinoma using dibiotinylated aluminum sulfophthalocyanine (0.25 mg/kg) resulted in enhanced inhibition of ...

Immunization with MFS-180 vaccine prepared in the presence of glutaraldehyde (0.05%), lipopolysaccharide (LPS) (100 micrograms/ml), and concanavalin A (Con A) (200 micrograms/ml) could protect Swiss mice against a subsequent challenge by 1 X 10(6) MFS-180 cells. The sequence of attachment of LPS and Con A to glutaraldehyde-treated cells as found to determine the efficacy of the vaccine. LPS cou...