Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent pharmacology. Mechanistic studies of ion channels typically involve sophisticated voltage-clamp protocols applied through manual or automated electr...

UNLABELLED In recent years there has been much development of the fundamental ideas underlying mathematical model curation in regard to models of biology. While much has been achieved in the realms of systems biology and bioinformatics, little progress has been made in relation to cellular electrophysiology modeling. The primary reason for slow progress in this field is the lack of a consistent...