The human papillomavirus (HPV) is the etiologic agent of cervical cancer. In this study, we provide evidence for the human Pygopus (hPygo)2 gene as a cellular biomarker for HPV-related disease. In a tumor microarray of cervical cancer progression, hPygo2 levels were greater in high-grade lesions and squamous cell carcinomas than in normal epithelia. Similarly, hPygo2 mRNA and protein levels wer...

BACKGROUND AND AIMS Chronic liver diseases are characterized by inflammatory and fibrotic liver injuries that often result in liver cirrhosis with its associated complications such as portal hypertension and hepatocellular carcinoma. Liver biopsy still represents the reference standard for fibrosis staging, although transient elastography is increasingly used for non-invasive monitoring of fibr...

Whether exposure of humans to extremely low frequency electromagnetic fields (ELF-EMF) can cause cancer is controversial and therefore needs further research. We used a Friend erythroleukemia cell line that can be chemically induced to differentiate to determine whether ELF-EMF could alter proliferation and differentiation in these cells in a manner similar to that of a chemical tumor promoter....

The authors evaluated the relation between occupational exposure to extremely low frequency (ELF) magnetic fields and mortality from cardiovascular diseases. The study was based on 27,790 subjects from the Swedish Twin Registry. Exposure to ELF magnetic fields was assessed by linking occupation reported in 1967 or 1973 to a job exposure matrix. Four levels of exposure were related to cause-spec...

Extremely low frequency magnetic field (ELF-MF) may result in oxidative DNA damage and lipid peroxidation with an ultimate effect on a number of systemic disturbances and cell death. The aim of the study is to assess the effect of ELF-MF parameters most frequently used in magnetotherapy on reactive oxygen species generation (ROS) in brain tissue of experimental animals depending on the time of ...

The present research was an attempt to shed more enlightening light on the current wave of English as a Lingua Franca (ELF), which is gradually sweeping the traditional ideologies in the field of ELT. To that end, this study examined the Iranian teacher trainees’ attitude towards ELF. What makes the present research markedly different from the other language attitude studies is in the context o...

Observing the shift to English as a Lingua Franca (ELF) in national curriculum for education, this study analyzes ELF-related features 2022 curriculum’s learning aims and evaluates their feasibility using text mining. The findings indicate that reflects ELF, example, by viewing medium of communication among diverse speakers whose first language is not English. emphasis on cultivating learners’ ...

Previous empirical studies have demonstrated that speakers of English as a lingua franca (ELF) display flexible use various pragmatic strategies (PSs) to support effective communication. However, date few investigated PSs usage from the perspective individual ELF speakers. Supported by Vygotskian Sociocultural ontogenetic view on pragmatics, this paper offers two qualitative case exploring firs...

The purpose of this study was to investigate the pharmacokinetic properties of colistin following intrapulmonary administration of colistin sulfate in rats. Colistin was infused or delivered in nebulized form at a dose of 0.35 mg/kg of body weight in rats, and plasma drug concentrations were measured for 4 h after administration. Bronchoalveolar lavages (BAL) were also conducted at 0.5, 2, and ...

We evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of posaconazole (POS) in a prospective, open-label study. Twenty-five healthy adults received 14 doses of POS oral suspension (400 mg twice daily) with a high-fat meal over 8 days. Pulmonary epithelial lining fluid (ELF) and alveolar cell (AC) samples were obtained via bronchoalveolar lavage, and blood samples were collected durin...