Abstract. In mathematical studies of molecular motors, the stochastic motor motion is modeled using the Langevin equation. If we consider an ensemble of motors, the probability density is governed by the corresponding Fokker-Planck equation. Average quantities, such as, average velocity, effective diffusion and randomness parameter, can be calculated from the probability density. The WPE method...

Several investigators have identified Epstein-Barr virus (EBV) particles in breast carcinomas, a fact that supports a role for EBV in mammary tumorigenesis. The possible mechanism involved in this process is not clear. The present study was carried out in an attempt to determine whether there is a relationship between latent infection with EBV and p53 and p63 expression in breast carcinomas. Im...

Probability functions such as likelihoods and genotype probabilities play an important role in the analysis of genetic data. When genotype data are incomplete Markov chain Monte Carlo (MCMC) methods, such as the Gibbs sampler, can be used to sample genotypes at the marker and trait loci. The Markov chain that corresponds to the scalar Gibbs sampler may not work due to slow mixing. Further, the ...

Plasmodium falciparum malaria remains a major cause of morbidity and mortality in many tropical countries, especially those in sub-Saharan Africa. Human genetic control of malaria infection is poorly understood; in particular, genes controlling P. falciparum blood infection levels remain to be identified. We recently evidenced the existence of complex genetic factors controlling blood infection...

Regulation of insurers’ use of genetic information means actuaries are interested in age-at-onset of genetic disorders. Arjas & Haara (1984) suggested marked point processes (MPPs) as useful models for life history data with complex covariates. Age-at-onset distributions (or equivalently, hazard rates) in respect of inherited disorders are often estimated from pedigrees, which are life historie...

In studies of molecular motors, the stochastic motion is modeled using the Langevin equation. If we consider an ensemble of motors, the probability density is governed by the corresponding Fokker–Planck equation. Average quantities, such as average velocity, effective diffusion coefficient, and randomness parameter, can be calculated from the probability density. A numerical method was previous...

BACKGROUND Breast cancer is a leading cause of death among women worldwide. Increasing evidence implies that human cytomegalovirus (HCMV) infection is associated with several malignancies. We aimed to examine whether HCMV is present in breast cancer and sentinel lymph node (SLN) metastases. MATERIALS AND METHODS Formalin-fixed paraffin-embedded tissue specimens from breast cancer and paired s...

In this paper we revisit various important issues relating to practical estimation of the multinomial probit model, using an empirical analysis of car ownership as a test case. To provide context, a brief literature review of empirical probit studies is included. Estimates are obtained for a full range of model specifications, including models with random (uncorrelated and correlated) taste var...

The Collaborative Study on the Genetics of Alcoholism (COGA) is a multicenter research program to detect and map susceptibility genes for alcohol dependence and related phenotypes. The measure M of "maximum number of drinks consumed in a 24-hour period" is closely related to alcoholism diagnosis in this dataset and provides a quantitative measure to grade nonalcoholic individuals. Twin studies ...