ORMAL DEVELOPMENT requires the regulation of N cell viability, growth, and differentiation to different lineages. Cell death occurs at specific times and sites in normal embryonic development, hence the name programmed cell death, which has also been called apoptosis.',2 This form of cell death by committing suicide is characterized by DNA degradation into fragments with sizes of one or more nu...

Mutations in MCOLN1, which encodes the cation channel protein TRPML1, result in the neurodegenerative lysosomal storage disorder Mucolipidosis type IV. Mucolipidosis type IV patients show lysosomal dysfunction in many tissues and neuronal cell death. The ortholog of TRPML1 in Caenorhabditis elegans is CUP-5; loss of CUP-5 results in lysosomal dysfunction in many tissues and death of developing ...

RE1-silencing transcription factor (Rest), also known as NRSF (neuro-restrictive silencer factor), is a negative regulator of neuron-specific genes and expressed during embryonic development to prevent neural gene expression in non-neuronal cells. However, Rest null mice die by E11.5, prior to which the growth retardation caused by widespread apoptotic cell death has precluded further analyses ...

background: different measures of mortality and morbidity statistics is a good tool in determining the health status of a community،the health network development and application of methods of prevention and treatment. basis of mortality data is the death certificate and the most important index in death certificate is accuracy of death causes with who standards and death causes codes in icd10....

Blockade of neuromuscular activity during the period of naturally occurring cell death increases intramuscular nerve branching, synaptogenesis, and survival of embryonic chicken motoneurons. These results suggested that the enhanced motoneuron survival observed might result not from increased production of a trophic factor by the target, as often suggested, but rather from the enhanced ability ...

Similar to other parts of the central nervous system, there are two types of programmed cell death during retinal development. In early development, the neuronal progenitor population is affected. In the mouse eye, this kind of programmed cell death begins at around embryonic day (E) 12.5 and peaks between E14.5 and E16.5. The second phase of programmed cell death occurs during synaptogenesis w...