The dismal outcome of pleuropericardial extramedullary multiple myeloma (EMM) reflects both the selection of resistant disease and absence of useful drugs. Carfilzomib and dexamethasone should be explored in advanced EMM patients, even for bortezomib-resistant patients, as may provide much longer overall survival than previously reported treatments.

BACKGROUND Intramyocardial cell injections in the context of cardiac regenerative therapy can currently be performed using electromechanical mapping (EMM) provided by the NOGA®XP catheter injection system. The gold standard technique to determine infarct size and location, however, is late gadolinium enhanced magnetic resonance imaging (LGE-MRI). In this article we describe a practical and accu...

The E-Learning Maturity Model (eMM) is a quality improvement framework designed to help institutional leaders assess their institution's e-learning maturity. This paper reviews the eMM, drawing on examples of assessments conducted in New Zealand, Australia, the UK and the USA to show how it helps institutional leaders assess and compare their institution's capability to sustainably develop, dep...

The incidence of invasive group A streptococcal disease has increased in Norway since the 1980s. Analysis of 100 isolates recovered from 1988 to 2003 showed an increased genotypic diversity over time, while the prevalence of the strain that dominated in 1988, sequence type (ST)-28/emm-1, decreased. Necrotizing fasciitis was often associated with ST-15/emm-3.

This paper establishes the Black Scholes formula in the martingale, risk-neutral valuation framework. The intent is two-fold. One, to serve as an introduction to expectation pricing and two, to examine this framework in explicit mathematical detail. The reader is assumed to have fluent background in the mathematical theory of stochastic processes and calculus, but is not assumed to have backgro...

BACKGROUND Accurate data on costs attributable to hospital-acquired infections are needed to determine their economic impact and the cost-benefit of potential preventive strategies. OBJECTIVE To determine the attributable costs of surgical site infection (SSI) and endometritis (EMM) after cesarean section by means of 2 different methods. DESIGN Retrospective cohort. SETTING Barnes-Jewish ...

Aims: The aims of our study were to determine epidemiological markers of S. pyogenes isolates as well as the antimicrobial activities against these strains and we determined the macrolide and tetracycline resistance genes. Methodology and Results: We studied the epidemiological markers of 148 Streptococcus pyogenes isolates collected from children in Tunisia between October 2000 and December 20...

We report the first case of a primary group A streptococcus (GAS) psoas abscess in a 31-year-old woman. The psoas abscess was preceded by an episode of acute pharyngitis. The M-protein gene (emm) and streptolysin S structural gene (sagA) were present in the isolate, with no significant amino acid differences from previously described sequences of M1 GAS isolates. Multilocus sequence typing (MLS...

Group A streptococci are model extracellular gram-positive pathogens responsible for pharyngitis, impetigo, rheumatic fever, and acute glomerulonephritis. A resurgence of invasive streptococcal diseases and rheumatic fever has appeared in outbreaks over the past 10 years, with a predominant M1 serotype as well as others identified with the outbreaks. emm (M protein) gene sequencing has changed ...

INTRODUCTION For the most part, literature and research around the benefits of computerized physician order entry (CPOE) and electronic medication management (EMM) have focused on the reduction of adverse events and medication errors. While these are major anticipated benefits relating to patient safety, the University Health Network (UHN) discovered that there are other unexpected benefits to ...