objective(s):the aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. quasi-emulsion solvent diffusion was used as a crystal modification method. materials and methods: corn starch was dissolved in hydrochloric acid at 80˚c and then ethanol as a non-solvent was added with lowering temperature ...

Purpose: To study the effect of some factors on the size of finasteride nano-emulsion by chemometric approach which could predict the size of nano-emulsion droplets under different conditions. Methods: Nano-emulsions were prepared using spontaneous emulsification method which occurs when organic and aqueous phases are mixed. The organic phase was a homogeneous solution of oil (finasteride as a ...

A high-performance liquid chromatography method was developed for the determination of related substances in an intravenous emulsion loaded with a paclitaxel-cholesterol complex. The separation was achieved using Agilent Eclipse XDB-C18 column (150×4.6 mm, 3.5 μm), which was kept at 40°. The gradient mobile phase consisted of acetonitrile and water with a flow rate of 1.2 ml/min. The ultraviole...

Four solidification methods for self-emulsifying drug delivery systems (SEDDS) were compared to evaluate the impact of on storage stability an incorporated protein. Papain was loaded in SEDDS via hydrophobic ion pairing (HIP). Liquid (l-SEDDS) either solidified by adsorption solid excipients such as magnesium-aluminometasilicate wet granulation (ssilica-SEDDS) and carbohydrates lyophilisation (...

The “gas–liquid two-phases mixed flow” mechanism that fine bubble generation uses rapidly swirling water, which shear gas and making small bubbles in water. Based on this mechanism, sending liquid such as oil into the water instead of it able to be emulsified. At present, evaluation methods for emulsions are using particle size distribution dispersion stability. However, emulsion with bad separ...

The purpose of this study was to prepare, optimize, and characterize a cationic lipid nanoparticle (CLN) system containing multicomponent drugs using a molecular dynamics model as a novel method of evaluating formulations. Puerarin (PUE) and scutellarin (SCU) were used as model drugs. CLNs were successfully prepared using melt-emulsion ultrasonication and low temperature-solidification techniqu...