نتایج جستجو برای: end resection
تعداد نتایج: 471996 فیلتر نتایج به سال:
The resection of DNA double strand breaks (DSBs) initiates homologous recombination (HR) and is critical for genomic stability. Using direct measurement of resection in human cells and reconstituted assays of resection with purified proteins in vitro, we show that DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a classic non-homologous end joining (NHEJ) factor, antagonizes DSB resec...
Giant cell tumor (GCT) involving distal ulna being rare with reported rate of 0.45-3% of all GCT cases; the literature has only sporadic cases reported. Various treatment options have been proposed, and dilemma exist whether to do resection alone or resection combined with stabilization or reconstruction. Also, there is no conclusive evidence regarding the method of stabilization or reconstruct...
Single-stranded DNA constitutes an important early intermediate for homologous recombination and damage-induced cell cycle checkpoint activation. In Saccharomyces cerevisiae, efficient double-strand break (DSB) end resection requires several enzymes; Mre11/Rad50/Xrs2 (MRX) and Sae2 are implicated in the onset of 5'-strand resection, whereas Sgs1/Top3/Rmi1 with Dna2 and Exo1 are involved in exte...
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