Epithelial stem/progenitor cells are considered as cancer initiating cells which has been detected in human endometrium, may initiate and progress endometrial carcinoma. Targeting cancer-initiating cells would be necessary to improve cure rates. The relation of endometrial adenocarcinoma and stem cell markers expression has not been reported yet, in spite of ALDH1 expression is frequently alter...

Lower-limb bone metastases are uncommon in low-grade endometrial carcinoma, and are mostly located on the axial skeleton. Here, we present a rare case of bilateral femur metastases in low-grade endometrial carcinoma and performed a review of the current literature.

OBJECTIVE To determine the sensitivity of MR imaging utilizing diffusion weighted imaging (DWI) in detection of endometrial cancer and to compare the Apparent Diffusion Coefficient (ADC) values of malignant and normal endometrium. STUDY DESIGN Cross-sectional analytical study. PLACE AND DURATION OF STUDY Radiology Department, Aga Khan University Hospital Karachi, from January 2007 to Decemb...

OBJECTIVES Epidemiological studies evaluating the association between adiponectin levels and endometrial carcinoma risk have produced inconsistent results. Thus, a meta-analysis was conducted to assess the association between them. METHODS Pertinent studies were identified by a search of PubMed and Web of Knowledge through January of 2015. A random-effects model was used to combine the data f...

PURPOSE Angiotensin (Ang) II was reported to induce vascular endothelial growth factor (VEGF) expression in various cells. Adipocyte-derived leucine aminopeptidase (A-LAP) is a novel member of the M1 family of zinc metallopeptidases. Enzymatic characterization demonstrated that A-LAP hydrolyzes Ang II. This study examined the role of A-LAP in angiogenesis of human endometrial carcinoma. EXPER...

OBJECTIVE The purpose of this study was to determine the value of endometrial blood flow assessment in predicting type 2 endometrial carcinoma. MATERIAL AND METHODS Sixty-five consecutive post-menopoausal women who had vaginal bleeding were enrolled in the study. All subjects were directed to transvaginal sonography to determine endometrial blood flow and underwent endometrial biopsy. Doppler...

BACKGROUND Cutaneous metastases from internal malignancies are uncommon. Moreover, endometrial carcinoma rarely metastasizes to the skin, with a reported prevalence of 0.8%. Here, we report the case of a 62-year-old woman who developed cutaneous metastases from an endometrial carcinoma. CASE PRESENTATION When admitted to our department, the patient underwent a biopsy that showed the presence ...

OBJECTIVES The aim of the study was to assess the concordance between the preoperative endometrial sampling and microscopic examination of the hysterectomy specimens in patients surgically treated for atypical endometrial hyperplasia and endometrial carcinoma. MATERIAL AND METHODS We analysed a group of 204 patients, of whom 160 (78.43%) underwent surgical treatment for cancer of the corpus u...

This is a case report of a 49-year-old woman who presented with offensive vaginal discharge. Her Lippes loop IUD was removed and discovered to have suspicious material attached. Histology report was of endometrial carcinoma. This is the first report of an endometrial carcinoma being completely removed along with an IUD.

BACKGROUND Serous carcinoma arising in adenomyosis and adenomyotic cyst is very rare. Only 3 serous carcinomas and 5 serous endometrial intraepithelial carcinomas (EIC) have been reported to date. METHODS We reviewed the clinicopathological features of 2 serous carcinoma in uterine adenomyosis and 1 serous EIC in adenomyotic cyst of the cervical stump. RESULTS Case 1 had an endometrial sero...