BACKGROUND Particularly interesting new cysteine-histidine rich protein (PINCH), as an adapter protein of the LIM family for signal transduction in the integrin and growth factor pathway, is upregulated in the stroma of several common types of cancers and involved in promoting tumor progression. In the present study, we examined PINCH expression in normal endometrium, atypical endometrial hyper...

The objective of the investigation was to compare the degree of interobserver agreement in determining the histological grade of uterine endometrial endometrioid adenocarcinoma using the criteria proposed by the three-grade FIGO classification (1988) and the new, two-grade system proposed by Lax et al. (2000). In the FIGO system, the assessment is focused on the amount of solid, non-squamous gr...

endometrial calcification along with ossification is an uncommon clinical entity. most of the cases are asymptomatic or present with secondary infertility. endometrial ossification associated with repeated abortions has been reported very infrequently. here we report a case of endometrial calcification with ossification  due to retained fetal bony tissue in a 38 year old symptomatic female havi...

background: endometrial remodeling occurs during each menstrual cycle in women. reports have shown that, in a variety of cell types, processes such as proliferation, signaling complex formation and extra cellular matrix remodeling require a cytoplasmic tyrosine kinase, focal adhesion kinase (fak). the present study has focused on the expression pattern of fak in human endometrium during the men...

BACKGROUND:: Various disorders lead to infertility in women of reproductive ages. This study was performed to describe the common ENDOMETRIAL causes of infertility and sonographic ,histerosalpingographic, and endometrial biopsy evaluation of these causes for midwives. IntroductionSuccessful implantation depends on interaction between a blastocyst and receptive endometrium. Different strategies ...

Beginning in October 2020 and ending April 2021, researchers from Al-Nahrain University's High Institute for Infertility Diagnosis Assisted Reproductive Technologies compared the success rates of two different methods diagnosing treating infertility. The major purpose research was to assess impact a combined trigger (follicle-stimulating hormone [FSH] human chorionic gonadotropin [hCG]) on endo...

BACKGROUND Endometrium acquires structural and functional competence for embryo implantation only during the receptive phase of menstrual cycle in fertile women. Sizeable data are available to indicate that this ability is acquired by modulation in the expression of several genes/gene products. However, there exists little consensus on the identity, number of expressed/not-detected genes and th...

BACKGROUND The elucidation of the molecular mechanisms by which the embryo contributes to its implantation is an area of extensive research. The main objective of this study was to investigate the pattern of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) secretion by human endometrial epithelium, and their regulation by human chorionic gonadotropin (hCG) and other growth factors pres...

BACKGROUND Endometrial cancer is the most common gynecologic malignancy that has often proceeded by a premalignant phase. Modern molecular and immunostaining methods for precancerous lesions diagnosis have been expanded. One of the genetic alternations in the endometrial cancer carcinogenesis is the mutational activation of the K-ras oncogene. K-ras mutation has recognized to occur at an early ...

BACKGROUND The presence of conceptus alloantigens necessitates changes in maternal immune function. One player in this process may be the macrophage. In the cow, there is large-scale recruitment of macrophages expressing CD68 and CD14 to the uterine endometrium during pregnancy. METHODOLOGY/PRINCIPAL FINDINGS In the present study, the function of endometrial macrophages during pregnancy was i...