نتایج جستجو برای: endothelial dysfunction
تعداد نتایج: 271850 فیلتر نتایج به سال:
investigated the role of calpain in the endothelial dysfunction of Ang II. Objective: To demonstrate a mechanistic role for calpain in the endothelial dysfunction induced by Ang II/AT1R signaling. To establish endothelial-expressed calpains as an important target of AT1R signaling. Methods and Results: Subchronic administration of nonpressor doses of Ang II to rats and mice significantly increa...
OBJECTIVE The purpose of the current study was to determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with coronary endothelial dysfunction and is a predictor of endothelial dysfunction in humans. METHODS AND RESULTS Patients (172) with no significant coronary artery disease (<30% stenosis) undergoing assessment of coronary endothelial function were studied. Endo...
BACKGROUND Diabetes mellitus is associated with microvascular and macrovascular diseases, potentially manifested as endothelial dysfunction. In adults with type 2 diabetes the haptoglobin genotype 1-1 has been shown to have a protective role in inhibiting the development of complications. Although complications from type 1 diabetes are infrequent during childhood, endothelial dysfunction, which...
The article contains the analysis of results concerning investigation adipocytokines content and endothelial dysfunction in 97 patients with irritable bowel syndrome associated obesity. blood serum was examined for (leptin, adiponectin, resistin), stable nitrogen monoxide metabolites (nitrites/nitrates), endothelin-1, intercellular adhesion molecule 1 (ICAM-1), number circulating cells (CEC). P...
Ca2+-activated Cl- channels play a crucial role in various physiological processes. However, the role of TMEM16A in vascular endothelial dysfunction during hypertension is unclear. In this study, we investigated the specific involvement of TMEM16A in regulating endothelial function and blood pressure and the underlying mechanism. Reverse transcription-polymerase chain reaction, Western blotting...
Although the burden of heart failure with preserved ejection fraction (HFpEF) is increasing, there is no therapy available that improves prognosis. Clinical trials using beta blockers and angiotensin converting enzyme inhibitors, cardiac-targeting drugs that reduce mortality in heart failure with reduced ejection fraction (HFrEF), have had disappointing results in HFpEF patients. A new "whole-s...
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