An in vitro model simulating two-compartment pharmacokinetics was used to study the antibacterial activity of lomefloxacin after single oral doses of 200 and 400 mg. Lomefloxacin produced reliable bactericidal activity against gram-negative aerobic bacteria and staphylococci. Bacterial strains for which MICs were less than 0.5 microgram/ml were inhibited with both dosing schedules. Doubling the...

A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possibl...

OBJECTIVES The purpose of this study was to assess the in vitro antibacterial activity of four formulations of calcium hydroxide [Ca(OH)(2)] pastes against Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus mutans. METHODS A broth dilution test was performed, and the lengths of time for different pastes to kill the microbial cells were recorded and statisti...

background and aim: bacterial elimination from root canal system is one of the aims in endodontic treatments, so the addition of antibiotics to sealers can increase their antimicrobial efficacy, as in this study we are determining the in-vitro antimicrobial effect of ah26 and ah plus sealers mixed with amoxicillin, triple antibiotic pastes and nanosilver on enterococcus faecalis. materials and ...

Materials and method Silver nanoparticles have gained more attention owing to their broad spectrum of antibacterial activity and low cost of manufacturing. In the present study, starch coated silver nanoparticle were synthesized and characterized by SEM/ EDX and UV/Vis spectroscopy. Starch coated nanosilver was tested for their antibacterial activity against various microorganisms that are comm...

Silver-based wound dressings have been developed for the control of bioburden in wounds. However, the popularity and extensive use of silver-based dressings has been associated with emerging microbial resistances to silver. In this study we examined in vitro antibacterial efficacy of a bioelectric dressing containing silver and zinc against various wound pathogens. Antibiotic-sensitive clinical...

Enterococcus faecalis rank among the leading causes of nosocomial infections worldwide and possesses both intrinsic and acquired resistance to a variety of antibiotics. Development of new antibiotics is limited, and pathogens continually generate new antibiotic resistance. Many researchers aim to identify strategies to effectively kill this drug-resistant pathogen. Here, we evaluated the effect...

Background: Various herbal products are being tried to treat common ailments. Such a trend is witnessed in dentistry also. gall extract of Quercus infectoria has been found to possess antibacterial properties against some common oral pathogens. Aim: to assess the antibacterial property and minimum inhibitory concentration (MIc) of gall extract of Quercus infectoria against Enterococcus faecalis...

Antimicrobial peptides (AMPs) are gaining popularity as alternatives for treatment of bacterial infections and recent advances in omics technologies provide new platforms for AMP discovery. We sought to determine the antibacterial activity of a novel antimicrobial peptide, buwchitin, against Enterococcus faecalis. Buwchitin was identified from a rumen bacterial metagenome library, cloned, expre...

Was evaluated the minimum inhibitory concentration (MIC) and the antibacterial effect (AE) of 2.5% NaOCl, 0.2% chlorhexidine gluconate (CHX) and 17% EDTA on Enterococcus faecalis. The antibacterial capacity was assessed by difusion in agar. The AE was evaluated on contaminated root dentin, employing apical and middle portions of human roots, sterilized and contaminated with Enterococcus faecali...