Nuclear envelope links to inherited disease gave the conundrum of how mutations in near-ubiquitous proteins can yield many distinct pathologies, each focused in different tissues. One conundrum-resolving hypothesis is that tissue-specific partner proteins mediate these pathologies. Such partner proteins may have now been identified with recent proteome studies determining nuclear envelope compo...

Long-term envelope modulations (< 100Hz) influence the identification of speech in noise. It is not clear, however, whether this influence only takes place at the level of acoustic-phonetic analysis (phonetic identification) or if envelope fluctuations may also help in auditory figureground segregation (e.g. separation of speech from concurrent backgrounds). An experiment is presented in which ...

Amplitude envelope co-varies with F0 in Mandarin lexical tones. It can cue lexical tone perception in a tone language such as Mandarin which uses different pitch contours for phonemic contrasts. The current study investigated whether amplitude envelope could also aid the perception of lexical tones in a language such as Cantonese which uses both pitch contour and relative pitch height for phone...

Retroviral vectors have been widely used in human gene therapy protocols. Entry into target cells is directed by the retroviral envelope protein, with receptor binding and postbinding fusion functions contributed mainly by the SU and TM subunits, respectively. We have generated mutants of the Moloney murine leukemia virus (MoMuLV) envelope protein with mutations in both the receptor binding dom...

A proline to serine mutation (P56S) in vesicle-associated membrane protein-associated protein B and C (VAPB) causes an autosomal dominant form of amyotrophic lateral sclerosis (ALS). We show that the mutation also causes a nuclear envelope defect. Transport of nucleoporins (Nups) and emerin (EMD) to the nuclear envelope is blocked, resulting in their sequestration in dilated cytoplasmic membran...

This paper examines binary filter design by jointly applying multiresolution design and envelope constraint. In multiresolution design, the value of the designed filter for a configuration is defined at a resolution sufficiently low to have observed the configuration. Preference is given to higher resolutions, but the number of training observations is taken into account. In envelope design, th...