External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA. Using murine cytomegalovirus (MCMV) as a model system, we examined the antiviral effects of an EGS variant, which was engineered using in vitro selection procedures...

Extensive reforms of India‟s indirect taxes at the central and the state levels has prepared the necessary ground for the implementation of a comprehensive goods and services tax (GST). The Empowered Committee of the State Finance Ministers in their First Discussion Paper and the Thirteenth Finance Commission in their recently submitted report have suggested GST models which are quite different...

The development of Enhanced Geothermal Systems (EGS) for the cogeneration of electricity and district heating has recently gained interest, and is expected to know an important development in the future. Major research questions on the design of the energy conversion system concern the increase of the efficiency in the usage of geothermal resources, as well as the increase of their economic pro...

The natural world generates a range of valuable goods and services that support human well–being. !ese goods and services, collectively called ecosystem services, are typically provided free of charge and often have characteristics of public goods. Like other public goods, ecosystem services will not be provided optimally by aggregating the decisions of individuals motivated by self–interest. F...

1. Introduction The question of value has been central to economics since its inception as a scientific discipline. The Classical economists thought deeply about the distinction between use value and exchange value and the relationship between human happiness and the market prices of goods and services. With the development of marginal value theory, beginning in the 1870s, the value problem see...

REASONS FOR PERFORMING STUDY Equine grass sickness (EGS) remains a frequently fatal disease of equids in Britain. Since previous investigations of signalment- and meteorology-related risk factors for EGS have yielded some conflicting data, further investigation is warranted. OBJECTIVES To identify signalment- and meteorology-related risk factors for EGS in Scotland. STUDY DESIGN Retrospecti...