In the major cancer research project conducted at this hospital, cytological, biochemical and biophysical changes that supervene in the epidermis of mice as a result of applications of methylcholanthrene have been followed. This approach to the problem of induction of malignancy has resulted in the discovery of distinct cellular and intercellular transformations leading to an early establishmen...

In this study we define the proliferative compartments of in vivo human epidermis, using specific antibodies related to cell differentiation (beta 1 and beta 4 integrins and K1/K10 differentiation keratins) and cell cycle (proliferating cell nuclear antigen [PCNA]) in combination with flow cytometric quantitation of the DNA content and optical characteristics of the cells. The beta 1 integrin (...

Silicic acid chromatography was employed to determine the distribution of the phosphatides in mouse epidermis undergoing normal growth changes induced by the hair growth cycle. These included epidermis removed 4, 12, and 22 days after plucking of the hair in both sexes of mice. Furthermore, the distribution of phosphatides was determined in mouse epidermis made hyperplastic by three, eighteen, ...

The epidermis is an important tissue in Homo sapines and other animals, and an abnormal epidermis will cause many diseases. Phosphatase 2A (PP2A) is an important serine and threonine phosphatase. The α isoform of the PP2A catalytic subunit (Ppp2ca gene encoding PP2Acα) is critical for cell proliferation, growth, metabolism and tumorigenesis. However, to date, no study has revealed its roles in ...

BACKGROUND Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). OBJECTIVE To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the IL-23/Th17 axis. METHODS This retrospective comparative immunohistochemical study was completed using 11 biopsies of 11 cases of ...

BACKGROUND Basal cell carcinoma (BCC) is a common malignant tumor and its incidence has risen in recent decades. Research has shown the relationship between ultraviolet (UV) radiation, the skin immune system, and BCC. The role of Langerhans cells (LC) in the immune response to tumors has prompted research into LC density and morphology in response to UV radiation and BCC. However, the data are ...

Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In this study, Panx1 and Panx3 were detected ...

There are several reports of electron microscopic studies on the epidermis of human fetuses and/or embryos: BREATHNACH and WYLLIE (1965a, 1965b) reported on the ultrastructure of the epidermis in human fetuses 12 and 14 weeks of menstrual age: RIEGEL (1965) in human fetuse 25 to 60mm long in crown-rump length; HASHIMOTO et al. (1966) in human fetuses 12 to 22 weeks of menstrual age, 60 to 180mm...

A mechanics model is developed for the encapsulated piezoelectric thin-film actuators/sensors system imperfectly bonded to the human skin to simultaneously determine the Young's moduli of the epidermis and dermis as well as the thickness of epidermis.