OBJECTIVES Estimate the causes and risk of death, specifically seizure related, in children followed from onset of epilepsy and to contrast the risk of seizure-related death with other common causes of death in the population. METHODS Mortality experiences from 4 pediatric cohorts of newly diagnosed patients were combined. Causes of death were classified as seizure related (including sudden u...

OBJECTIVE To identify the rate of successful antiepileptic drug (AED) withdrawal after resective surgery and the predictors of postwithdrawal seizure recurrence in patients with extratemporal epilepsy. METHODS We retrospectively analyzed the postoperative AED profile of 106 consecutive patients who had completed 2 or more years after resections involving frontal, parietal, and occipital lobes...

PURPOSE Studies on seizures only with an alteration of consciousness were limited mainly to generalized epilepsy. This seizure type has been described rarely in focal epilepsy. We aimed to analyze the semiologic features of this seizure type in focal and generalized epilepsies in a blinded design. METHODS A total of 338 seizure videos in 100 patients were included exclusively by semiologic cr...

Automatic seizure detection is becoming popular in modern epilepsy monitoring units since it assists diagnostic monitoring and reduces manual review of large volumes of EEG recordings. In this paper, we describe the application of machine learning algorithms for building patient-specific seizure detectors on multiple frequency bands of intra-cranial electroencephalogram (iEEG) recorded by a den...

Epilepsy is considered to be one of the most common and disabling diseases, yet we still do not have a sufficient understanding detailed pathophysiology this condition and, as well treatment rationale for much epilepsy. This article reviews clinical aspects epilepsy seizure intending provide physicians an insight into that might tractable scientific investigations. defined, diagnostic methods a...

Electrocardiography has added value to automatically detect seizures in temporal lobe epilepsy (TLE) patients. The wired hospital system is not suited for a long-term seizure detection system at home. To address this need, the performance of two wearable devices, based on electrocardiography (ECG) and photoplethysmography (PPG), are compared with hospital ECG using an existing seizure detection...

Human studies show a link between stress and epilepsy, with stress causing an increase in seizure frequency and severity in patients with epilepsy. Many different animal model systems have been used to better understand this connection and the possible mechanisms involved. This review highlights the results of such studies relating stress and seizure susceptibility, with a focus on the hypothal...

An automatic detection system for distinguishing normal, ictal, and interictal electroencephalogram (EEG) signals is of great help in clinical practice. This paper presents a three-class classification system based on discrete wavelet transform (DWT) and the nonlinear sparse extreme learning machine (SELM) for epilepsy and epileptic seizure detection. Three-level lifting DWT using Daubechies or...

The long-term effects of vagus nerve stimulation (VNS) on seizure frequency were studied in 50 patients with epilepsy and learning disabilities. Mean observation time was 4.6 years. At follow-up, none of the patients was seizure-free, 25% had more than 50% seizure reduction, and 46% had some seizure reduction, but less than 50%. The discontinuation rate was 18%. Our results indicate that, like ...

PURPOSE Epilepsy is the commonest serious neurological condition to affect adolescents. We established a nurse-led clinic for young people with suspected or diagnosed epilepsy. Outcomes in all patients referred during the first 4 years after its inception are reported. METHODS A total of 301 adolescents were seen at the clinic during 1996-1999. Epilepsy was excluded in 135 (45%), including 5 ...