perivascular epithelioid cell tumor (pecoma) is composed of hmb45+ epithelioid cells with clear to granular cytoplasm and perivascular distribution. we describe a uterine pecoma in a 33 years old woman where tumor cells were positive for hmb45 but negative for epithelial markers and negative or positive for smooth muscles markers.

Abstract The transcription factor E74-like 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role ELF3 bile duct cells by identifying several previously unknown direct target genes that appear to be implicated carcinogenesis. directly repressed ZEB2, key regulator epithelial–mesenchymal transition, and upregulated ex...

Aim: To find the clinical association of cervical cancer with pap smear test. Study Design: Prospective study Place and Duration Study: Department Obstetrics & Gynaecology, AJK Medical College Muzaffarbad Azad Kashmir from 1st January 2021 to 30th June 2022. Methodology: Five hundred women were screened who between 20-55 years age. Sampling was performed by ecto-cervix through wooden Ayre s...

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Sweksha Lohani author on ‘ A novel role for PRL regulating epithelial cell density by inducing apoptosis at confluence’, JCS. postdoctoral researcher lab Hiroaki Miki Department Cellular Regulation,...

Increased expression of Bcl-2 protein has been demonstrated in various cancerous and precancerous lesions. The B-cell lymphoma-2 gene is a proto-oncogene that inhibits apoptosis, therefore keeping the cell alive. Mutations leads to an overexpression products leading apoptosis impairment resulting neoplastic changes as consequence. Hence, objective study was investigate fibro epithelial polyp (F...

Studies of electric effects in biological systems, from the work on action potential to studies limb regeneration or wound healing, commonly focus transitory behaviour and not addressing question homeostasis. Here we use a microfluidic device study how homeostasis confluent epithelial tissues is modified when transepithelial difference that different natural one imposed an layer. When field dir...

results there were 39 cases with lymph node metastasis in 59 malignant tumors, and 0 cases in 6 benign follicular type tumors. the staining scores by jt-95 of the 39 tumors with lymph node metastasis were 5+ in eight cases and 6+ in 31 cases. on the other hand, the scores of 20 malignant tumors without lymph node metastasis were < 4+ in all of the cases. in the co-cultured assay, numerous adhes...

introduction to evaluate the expression patterns of cytokeratin (k) 12, 13, and 19 in normal epithelium of the human ocular surface to determine whether k13 could be used as a marker for conjunctival epithelium. methods: total rna was isolated from the human conjunctiva and central cornea. those transcripts that had threefolds or higher expression levels in the conjunctiva than the cornea were ...