Epithelial cells play a major role in animal and human homeostasis because they selectively regulate the exchange of solutes between two given media, such as blood or urine. Cardiac glycosides (CG) are group highly toxic compounds whose best therapeutic known effect is on heart, although recent evidence has shown that it exerts wide range physiological effects tissues other than heart. Prostagl...

BACKGROUND/AIM The kd/kd mouse spontaneously develops severe and progressive nephritis leading to renal failure, characterized by cellular infiltration, tubular destruction and glomerular sclerosis. Recent identification of the mutant gene and the observation that podocytes are affected, led to the hypothesis that there are primary renal epithelial cell defects in this strain. METHODS Clinica...

a new series of anti-cancer agents based on 1,2-diaryl-5,6-dihydropyrrolo[2,1-a]isoquinoline scaffold containing n,n-diethylamino ethoxy, piperidinyl ethoxy or morpholinyl ethoxy group at the para position of the c-2 phenyl ring were synthesized and their cytotoxic activities were assessed against several human cancer cell lines including mcf-7 (er positive breast cancer cell), mda-mb231 (er-ne...

Objective: The objective of the study was to various renal manifestations in sickle cell disease (SCD) and establish a cause effect relationship with evaluation risk factors. Methods: This prospective observational cross-sectional conducted on 82 SCD patients belonging age group 15–50 years both genders over period 2 from January 2019 December 2020 MKCG Medical College Hospital, Berhampur, Odis...

PURPOSE This was an exploratory study to test two hypotheses related to potential epithelial precursors to ovarian cancer: (a) histologically normal ovarian surface epithelium exhibited changes in the nuclear chromatin pattern, which indicate an ovarian abnormality, and (b) such changes were detectable in the ovarian surface epithelium of cancer-free subjects who were at high risk for ovarian c...

INTRODUCTION Gingiva fibromatosis is a relatively rare condition characterized by diffuse enlargement of the gingiva, which is caused by expansion and accumulation of the connective tissue. OBJECTIVE The aim of the present study was to investigate proliferative and apoptotic biomarker expression in normal gingiva and two forms of gingival fibromatosis. METHODS Archived tissue specimens of h...

Background and Aim: Oral mucosal lesions have various prevalence rates among different populations. Few studies have evaluated the frequency of oral mucosal lesions in Iranian population. This study aimed to determine the frequency of oral mucosal lesions and the related factors.                   &nb...

More than 90% of epithelial ovarian cancers are clonal neoplasms that arise from the progeny of a single cell (1-3). Comparison of primary and metastatic sites from the same patient has detected similar patterns of loss of heterozygosity (LOH) on different chromosomes, inactivation of the same X chromosome, and identical mutations in the p53 gene in primary and secondary tumors. Given the clona...