Prior test experience compromises the anxiolytic efficacy of benzodiazepines (BZs) either in rats or mice, a phenomenon not exclusive to the elevated plus-maze (EPM) animal model of anxiety, which is referred to as "one-trial tolerance." However, it remains to be determined whether a similar event occurs when testing other drugs that also possess binding-sites on the GABA(A) receptor, such as e...

Departamento de Neurologia, Psiquiatria e Psicologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto SP, Brazil; Departamento de Fisiologia, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), São Paulo SP, Brazil; Disciplina de Neurologia Experimental, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), São P...

Plus-maze following the microinjection of muscimol into the dorsal periaqueductal gray of the rat Performance no labirinto em cruz elevado após microinjeção de muscimol na substância cinzenta periaquedutal dorsal do rato Dear Editor, Some experimental findings have indicated that the rat dorsal periaqueductal gray (DPAG) is part of a longitudinally organized neural system responsible for behavi...

To exploit the application of the on-chip cell electrophoresis system to the monitoring of the progress of cellular differentiation, the temporal change in the electrophoretic mobility (EPM) of human promyelocytic leukemia cell lines (HL60) during neutrophil differentiation was systematically investigated. Firstly, to confirm the action of two differentiation inducers, all-trans retinoic acid (...

The study evaluates the possibility of enhancing uptake of etoposide (topoisomerase II inhibitor) by tumor when delivered through polysorbate 20 micelles. The micelle formation was ascertained by determining the critical micellar concentration (CMC) with a du Nouy ring tensiometer and by size measurement using dynamic light scattering. Addition of 5% ethanol decreased the CMC of Polysorbate 20 ...

The friction factor is a key input for “barrel compression test” and meaningful interpretation of the test data. Despite its widespread use, due to complexity problem, there are very few solutions available test, let alone factor. Extended-Avitzur (EA) model has serious known limitations calculate To estimate more reliably, closed-form solution been proposed here. based on “Exponential Profile ...

The Gender Source Book is organised into 3 parts. Part One presents the essence of the Source Book, (a) the context and the concept of gender responsive environmental planning and management (EPM), (b) the process of gender responsive EPM, drawn lessons of experiences from cities and programmes, and (c) the lessons learnt and challenges. Part Two contains the summaries of twenty practical case ...

Objective Royal jelly is a honey bee secretion with beneficial effects on the nervous system. The present study aims to investigate of royal in reducing seizure and anxiety-like behaviors Syrian rats. Methods This an experimental study. In model, 25 male white rats were randomly divided into five groups: Control, 100 mg/kg, 200 400 phenobarbital. After 30 minutes, strychnine was injected induce...

OBJECTIVE The present study was carried out to investigate the neuropharmacological activities of ethyl acetate extract of Mimosa pudica (EAMP) leaves on anxiety, depression and memory in a mouse model. MATERIALS AND METHODS Anti-anxiety potential of EAMP was evaluated by elevated plus maze (EPM), light-dark box (LDB) and social interaction (SI) tests in mice.Anti-depressant potential of EAMP...