Human ether-à-go-go-related gene ( HERG) encodes a K channel similar to the rapid delayed rectifier channel current ( I Kr) in cardiac myocytes. Modulation of I Kr by extracellular acidosis under pathological conditions may impact on cardiac electrical activity. Therefore, we studied the effects of extracellular acidification on I Kr function and the underlying mechanism, using HERGexpressed in...

K(+) channels encoded by the human ether-à-go-go-related gene (HERG) are distinguished from most other voltage-gated K(+) channels by an unusually slow deactivation process that enables cardiac I(Kr), the corresponding current in ventricular cells, to contribute to the repolarization of the action potential. When the first 16 amino acids are deleted from the amino terminus of HERG, the deactiva...

the purpose of this research was to study and predict fuel consumption rate of tractor due to different aspect ratios of chisel plow blade and to determine a general relationship equation between aspect ratio ( ) and fuel consumption rate.  an itm-399 (81 kw) tractor and a mounted-type chisel plow with 9 shanks were used. the 5 and 10 cm width chisel blades were used. the experiments were condu...

The enzymatic synthesis of organic compounds in continuous bioreactors is an efficient way to obtain industrially important chemicals. However, few works have focused on the study of the operational conditions and the bioprocess performance. In this work, the aliphatic ester pentyl octanoate was obtained by direct esterification using a continuous packed bed bioreactor containing the immobilize...

Efficient single-photon detection by retinal rod photoreceptors requires timely and reproducible deactivation of rhodopsin. Like other G protein-coupled receptors, rhodopsin contains multiple sites for phosphorylation at its COOH-terminal domain. Transgenic and electrophysiological methods were used to functionally dissect the role of the multiple phosphorylation sites during deactivation of rh...

Abstract Studying the motion of Lennard-Jones clusters in an external potential having a very narrow channel passage at the saddle point, we present a one point boundary scheme to numerically sample transition (reaction) paths. This scheme does not require knowledge of the transition states (saddle points) or that of the final states. A transition path within a given time interval (0, tf ) cons...

The mechanism of crossed cerebellar diaschisis (CCD) is considered to be secondary hypoperfusion due to neural deactivation. To elucidate the hemodynamics during neural deactivation, the hemodynamics of CCD was investigated. The cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF), cerebral metabolic rate of oxygen (CMRO2), and vascular responses to ...