Physico-chemical investigation of urolithiasis today is mostly focused on applying physico-chemical description of precipitation processes to the stone formation with the aim to distinguish between stone formers and nonstone formers. This is done by calculating supersaturation for different solid phases which can be formed in urine using data obtained by urine analysis and existing solubility p...

The limiting solubility of fatty acids in micellar solutions of the anionic surfactant sodium laurylethersulfate (SLES) and the zwitterionic surfactant cocamidopropyl betaine (CAPB) is experimentally determined. Saturated straight-chain fatty acids with n=10, 12, 14, 16, and 18 carbon atoms were investigated at working temperatures of 25, 30, 35, and 40°C. The rise of the fatty acid molar fract...

Specific biopharmaceutics classification investigation and study on phamacokinetic profile of a novel drug candidate (2-methylcarbamoyl-4-{4-[3- (trifluoromethyl) benzamido] phenoxy} pyridinium 4-methylbenzenesulfonate monohydrate, NCE) were carried out. Equilibrium solubility and intrinsic dissolution rate (IDR) of NCE were estimated in different phosphate buffers. Effective intestinal permeab...

Cyclodextrins (CDs) have been extensively utilized as host molecules to enhance the solubility, stability and bioavailability of hydrophobic drug molecules through the formation of inclusion complexes. It was previously reported that the use of co-solvents in such studies may result in ternary (host:guest:co-solvent) complex formation. The objective of this work was to investigate the effect of...

This study concerns a new antiretroviral drug named CRS 74, which has a limited bioavailability because of its low aqueous solubility and dissolution rate. To improve these properties, CRS 74 can be recrystallized by using Liquid Anti-Solvent (LAS) crystallization. Ethanol is chosen as the solvent under study for the molecule and water as the anti-solvent. Since solubility data is limited, it i...

The molar absorptivity curves of the mono and bis nickel(II) complexes of 2,2'-bipyridine and 1,10-phenanthroline have been deduced from the composite absorbance data of a series of equilibrium solutions in methanol using equilibrium-restricted factor analysis, a technique for extracting spectral and thermodynamic information for component species involved in solution equilibria. The solutions ...

Group contribution methods such as the UNIFAC are of major interest to researchers and engineers involved synthesis, feasibility studies, design and optimization of separation processes as well as other applications of industrial use. Reliable knowledge of the phase equilibrium behavior is crucial for the prediction of the fate of the chemical in the environment and other applications. The obje...

among various reported membrane-based gas separation processes, the best explanation is generally achieved by the solution-diffusion model. the main factors in this model are the solubility and diffusivity of permeationcomponents through the membrane. the prediction of permeability and diffusivity in multicomponent gas permeation as well as the separation evaluation equilibrium and kinetic inte...

A novel technique for silver extraction from Ag2S is described. The method utilizes thiosulphate as complexing reagent and the redox reaction between SO2 added as Na2SO3 powder and H2S gas evolved. The parameters of the reaction such as pH, the reaction temperature, the complex equilibrium of Ag ion with thiosulphate and the solubility of Ag2S were investigated. Silver ions, obtained by this me...

Gamma-hydroxybutyrate / butyric acid, ambiguously called GHB, presents some unique challenges for analysis due in part to its acidity, high polarity, and high solubility in aqueous solution. Its chemistry is complicated by its conversion into the corresponding lactone compound, where the GHB molecule condenses to form a cyclic ester with a five-membered ring. This compound, gamma-butyrolactone ...